Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220676525> ?p ?o ?g. }
- W4220676525 endingPage "287" @default.
- W4220676525 startingPage "277" @default.
- W4220676525 abstract "Cognitive impairments in schizophrenia are associated with lower gamma oscillation power in the prefrontal cortex (PFC). Gamma power depends in part on excitatory drive to fast-spiking parvalbumin interneurons (PVIs). Excitatory drive to cortical neurons varies in strength, which could affect how these neurons regulate network oscillations. The authors investigated whether variability in excitatory synaptic strength across PVIs could contribute to lower prefrontal gamma power in schizophrenia.In postmortem PFC from 20 matched pairs of comparison and schizophrenia subjects, levels of vesicular glutamate transporter 1 (VGlut1) and postsynaptic density 95 (PSD95) proteins were quantified to assess variability in excitatory synaptic strength across PVIs. A computational model network was then used to simulate how variability in excitatory synaptic strength across fast-spiking (a defining feature of PVIs) interneurons (FSIs) regulates gamma power.The variability of VGlut1 and PSD95 levels at excitatory inputs across PVIs was larger in schizophrenia relative to comparison subjects. This alteration was not influenced by schizophrenia-associated comorbid factors, was not present in monkeys chronically exposed to antipsychotic medications, and was not present in calretinin interneurons. In the model network, variability in excitatory synaptic strength across FSIs regulated gamma power by affecting network synchrony. Finally, greater synaptic variability interacted synergistically with other synaptic alterations in schizophrenia (i.e., fewer excitatory inputs to FSIs and lower inhibitory strength from FSIs) to robustly reduce gamma power.The study findings suggest that greater variability in excitatory synaptic strength across PVIs, in combination with other modest synaptic alterations in these neurons, can markedly lower PFC gamma power in schizophrenia." @default.
- W4220676525 created "2022-04-03" @default.
- W4220676525 creator A5044949178 @default.
- W4220676525 creator A5047091057 @default.
- W4220676525 creator A5047966065 @default.
- W4220676525 date "2022-04-01" @default.
- W4220676525 modified "2023-10-17" @default.
- W4220676525 title "Synaptic Variability and Cortical Gamma Oscillation Power in Schizophrenia" @default.
- W4220676525 cites W1487695731 @default.
- W4220676525 cites W1599788775 @default.
- W4220676525 cites W1969171865 @default.
- W4220676525 cites W1971347175 @default.
- W4220676525 cites W1971677675 @default.
- W4220676525 cites W1984660568 @default.
- W4220676525 cites W1988282606 @default.
- W4220676525 cites W1989512479 @default.
- W4220676525 cites W1989973456 @default.
- W4220676525 cites W1992910467 @default.
- W4220676525 cites W1997950587 @default.
- W4220676525 cites W1999251867 @default.
- W4220676525 cites W2000467379 @default.
- W4220676525 cites W2001954021 @default.
- W4220676525 cites W2025806474 @default.
- W4220676525 cites W2030773781 @default.
- W4220676525 cites W2031743812 @default.
- W4220676525 cites W2034965090 @default.
- W4220676525 cites W2047347093 @default.
- W4220676525 cites W2054728313 @default.
- W4220676525 cites W2055395405 @default.
- W4220676525 cites W2056179112 @default.
- W4220676525 cites W2057355158 @default.
- W4220676525 cites W2059668389 @default.
- W4220676525 cites W2061681507 @default.
- W4220676525 cites W2065286706 @default.
- W4220676525 cites W2067853970 @default.
- W4220676525 cites W2081720232 @default.
- W4220676525 cites W2083496120 @default.
- W4220676525 cites W2089823661 @default.
- W4220676525 cites W2092726530 @default.
- W4220676525 cites W2096247801 @default.
- W4220676525 cites W2097965856 @default.
- W4220676525 cites W2099156854 @default.
- W4220676525 cites W2102125031 @default.
- W4220676525 cites W2102293491 @default.
- W4220676525 cites W2103592460 @default.
- W4220676525 cites W2103905237 @default.
- W4220676525 cites W2108130753 @default.
- W4220676525 cites W2124289190 @default.
- W4220676525 cites W2125788186 @default.
- W4220676525 cites W2129208121 @default.
- W4220676525 cites W2129452432 @default.
- W4220676525 cites W2136396374 @default.
- W4220676525 cites W2136539651 @default.
- W4220676525 cites W2149561999 @default.
- W4220676525 cites W2156026059 @default.
- W4220676525 cites W2157084876 @default.
- W4220676525 cites W2157239334 @default.
- W4220676525 cites W2159400463 @default.
- W4220676525 cites W2161547851 @default.
- W4220676525 cites W2162013747 @default.
- W4220676525 cites W2162916231 @default.
- W4220676525 cites W2165702601 @default.
- W4220676525 cites W2167126500 @default.
- W4220676525 cites W2170527455 @default.
- W4220676525 cites W2170696995 @default.
- W4220676525 cites W2268380328 @default.
- W4220676525 cites W2490214293 @default.
- W4220676525 cites W2551596589 @default.
- W4220676525 cites W2553225945 @default.
- W4220676525 cites W2735735043 @default.
- W4220676525 cites W2784079369 @default.
- W4220676525 cites W2794340861 @default.
- W4220676525 cites W2898524098 @default.
- W4220676525 cites W2952921509 @default.
- W4220676525 cites W3024584290 @default.
- W4220676525 cites W3131785587 @default.
- W4220676525 cites W3187020241 @default.
- W4220676525 cites W4249205036 @default.
- W4220676525 doi "https://doi.org/10.1176/appi.ajp.2021.21080798" @default.
- W4220676525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35360919" @default.
- W4220676525 hasPublicationYear "2022" @default.
- W4220676525 type Work @default.
- W4220676525 citedByCount "13" @default.
- W4220676525 countsByYear W42206765252022 @default.
- W4220676525 countsByYear W42206765252023 @default.
- W4220676525 crossrefType "journal-article" @default.
- W4220676525 hasAuthorship W4220676525A5044949178 @default.
- W4220676525 hasAuthorship W4220676525A5047091057 @default.
- W4220676525 hasAuthorship W4220676525A5047966065 @default.
- W4220676525 hasBestOaLocation W42206765252 @default.
- W4220676525 hasConcept C112592302 @default.
- W4220676525 hasConcept C15744967 @default.
- W4220676525 hasConcept C169760540 @default.
- W4220676525 hasConcept C169900460 @default.
- W4220676525 hasConcept C17077164 @default.
- W4220676525 hasConcept C2781195155 @default.
- W4220676525 hasConcept C86803240 @default.
- W4220676525 hasConceptScore W4220676525C112592302 @default.