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• W4220676878 startingPage "2155" @default.
• W4220676878 abstract "Aim: To compare pembrolizumab with competing interventions for previously untreated, unresectable or metastatic microsatellite instability-high or mismatch repair-deficient colorectal cancer. Method: Trials were identified via a systematic literature review and synthesized using a Bayesian network meta-analysis with time-varying hazard ratios (HRs). Results: Using intention-to-treat data, HRs for overall survival were generally in favor of pembrolizumab but not statistically significant; however, statistical significance was reached versus all comparators by month 16 when accounting for crossover. Estimated HRs for progression-free survival significantly favored pembrolizumab versus all comparators by month 12. Pembrolizumab was also superior to all comparators in terms of grade ≥3 adverse events. Conclusion: These analyses suggest that pembrolizumab is a highly efficacious and safe treatment in this population." @default.
• W4220676878 created "2022-04-03" @default.
• W4220676878 creator A5000893915 @default.
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• W4220676878 creator A5047503603 @default.
• W4220676878 creator A5050381719 @default.
• W4220676878 date "2022-06-01" @default.
• W4220676878 modified "2023-10-14" @default.
• W4220676878 title "Systematic literature review and network meta-analysis of pembrolizumab versus other interventions for previously untreated, unresectable or metastatic, MSI-high or MMR-deficient CRC" @default.
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