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• W4220677637 abstract "Fluctuations in the number of nascent RNA accurately reflect transcriptional activity. However, mathematical models predicting their distributions are difficult to solve analytically due to their non-Markovian nature stemming from transcriptional elongation. Here we circumvent this problem by deriving an exact relationship between the steady-state distribution of nascent RNA and the distribution of initiation times, which can be computed for any general initiation mechanism described by a set of first-order reactions. We test our theory using simulations and live cell imaging data." @default.
• W4220677637 created "2022-04-03" @default.
• W4220677637 creator A5028343194 @default.
• W4220677637 creator A5029788536 @default.
• W4220677637 date "2022-03-30" @default.
• W4220677637 modified "2023-09-28" @default.
• W4220677637 title "Steady-state distributions of nascent RNA for general initiation mechanisms" @default.
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• W4220677637 doi "https://doi.org/10.1101/2022.03.30.486441" @default.
• W4220677637 hasPublicationYear "2022" @default.
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