Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220677977> ?p ?o ?g. }
- W4220677977 endingPage "488" @default.
- W4220677977 startingPage "488" @default.
- W4220677977 abstract "Research on the intracerebral mechanism of insomnia induced by serotonin (5-HT) deficiency is indispensable. In order to explore the effect of 5-HT deficiency-induced insomnia on brain regions related to memory in rats, we designed and fabricated a microelectrode array that simultaneously detects the electrical activity of the dorsal raphe nucleus (DRN) and hippocampus in normal, insomnia and recovery rats in vivo. In the DRN and hippocampus of insomnia rats, our results showed that the spike amplitudes decreased by 40.16 and 57.92%, the spike repolarization slope decreased by 44.64 and 48.59%, and the spiking rate increased by 66.81 and 63.40%. On a mesoscopic scale, the increased firing rates of individual neurons led to an increased δ wave power. In the DRN and hippocampus of insomnia rats, the δ wave power increased by 57.57 and 67.75%. Furthermore, two segments' δ wave slopes were also increased in two brain regions of the insomnia rats. Our findings suggest that 5-HT deficiency causes the hyperactivity of neurons in the hippocampus and DRN; the DRN's firing rate and the hippocampal neuronal amplitude reflect insomnia in rats more effectively. Further studies on alleviating neurons affected by 5-HT deficiency and on achieving a highly effective treatment for insomnia by the microelectrode array are needed." @default.
- W4220677977 created "2022-04-03" @default.
- W4220677977 creator A5003917889 @default.
- W4220677977 creator A5027748236 @default.
- W4220677977 creator A5035726040 @default.
- W4220677977 creator A5037015805 @default.
- W4220677977 creator A5040147974 @default.
- W4220677977 creator A5043616119 @default.
- W4220677977 creator A5072419002 @default.
- W4220677977 creator A5078043039 @default.
- W4220677977 date "2022-03-21" @default.
- W4220677977 modified "2023-10-14" @default.
- W4220677977 title "PtNPs/Short MWCNT-PEDOT: PSS-Modified Microelectrode Array to Detect Neuronal Firing Patterns in the Dorsal Raphe Nucleus and Hippocampus of Insomnia Rats" @default.
- W4220677977 cites W1523726879 @default.
- W4220677977 cites W1950671782 @default.
- W4220677977 cites W1971729817 @default.
- W4220677977 cites W1978295404 @default.
- W4220677977 cites W2003587629 @default.
- W4220677977 cites W2011580879 @default.
- W4220677977 cites W2037282475 @default.
- W4220677977 cites W2050407694 @default.
- W4220677977 cites W2065827986 @default.
- W4220677977 cites W2076327464 @default.
- W4220677977 cites W2085957678 @default.
- W4220677977 cites W2090374468 @default.
- W4220677977 cites W2124761808 @default.
- W4220677977 cites W2163166459 @default.
- W4220677977 cites W2330739135 @default.
- W4220677977 cites W2414097325 @default.
- W4220677977 cites W2605277320 @default.
- W4220677977 cites W2610621727 @default.
- W4220677977 cites W2615609848 @default.
- W4220677977 cites W2718983846 @default.
- W4220677977 cites W2751178603 @default.
- W4220677977 cites W2762238975 @default.
- W4220677977 cites W2767493192 @default.
- W4220677977 cites W2769923600 @default.
- W4220677977 cites W2792526188 @default.
- W4220677977 cites W2799328995 @default.
- W4220677977 cites W2799891267 @default.
- W4220677977 cites W2806885331 @default.
- W4220677977 cites W2898537644 @default.
- W4220677977 cites W2901335588 @default.
- W4220677977 cites W2908517481 @default.
- W4220677977 cites W2924166171 @default.
- W4220677977 cites W2932681718 @default.
- W4220677977 cites W2950452968 @default.
- W4220677977 cites W2992034795 @default.
- W4220677977 cites W2993953425 @default.
- W4220677977 cites W3036566225 @default.
- W4220677977 cites W3085158981 @default.
- W4220677977 cites W3092210409 @default.
- W4220677977 cites W3120772290 @default.
- W4220677977 cites W3122344032 @default.
- W4220677977 cites W3138201991 @default.
- W4220677977 cites W3162478028 @default.
- W4220677977 cites W3183284721 @default.
- W4220677977 cites W3199266397 @default.
- W4220677977 cites W4200392556 @default.
- W4220677977 cites W4213298655 @default.
- W4220677977 cites W4241718126 @default.
- W4220677977 cites W953064605 @default.
- W4220677977 doi "https://doi.org/10.3390/mi13030488" @default.
- W4220677977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35334780" @default.
- W4220677977 hasPublicationYear "2022" @default.
- W4220677977 type Work @default.
- W4220677977 citedByCount "3" @default.
- W4220677977 countsByYear W42206779772022 @default.
- W4220677977 countsByYear W42206779772023 @default.
- W4220677977 crossrefType "journal-article" @default.
- W4220677977 hasAuthorship W4220677977A5003917889 @default.
- W4220677977 hasAuthorship W4220677977A5027748236 @default.
- W4220677977 hasAuthorship W4220677977A5035726040 @default.
- W4220677977 hasAuthorship W4220677977A5037015805 @default.
- W4220677977 hasAuthorship W4220677977A5040147974 @default.
- W4220677977 hasAuthorship W4220677977A5043616119 @default.
- W4220677977 hasAuthorship W4220677977A5072419002 @default.
- W4220677977 hasAuthorship W4220677977A5078043039 @default.
- W4220677977 hasBestOaLocation W42206779771 @default.
- W4220677977 hasConcept C111670793 @default.
- W4220677977 hasConcept C126322002 @default.
- W4220677977 hasConcept C147789679 @default.
- W4220677977 hasConcept C148762608 @default.
- W4220677977 hasConcept C15744967 @default.
- W4220677977 hasConcept C169760540 @default.
- W4220677977 hasConcept C170493617 @default.
- W4220677977 hasConcept C17525397 @default.
- W4220677977 hasConcept C185592680 @default.
- W4220677977 hasConcept C2775864247 @default.
- W4220677977 hasConcept C2777865548 @default.
- W4220677977 hasConcept C2781161787 @default.
- W4220677977 hasConcept C32610206 @default.
- W4220677977 hasConcept C37000724 @default.
- W4220677977 hasConcept C71924100 @default.
- W4220677977 hasConcept C74254510 @default.
- W4220677977 hasConcept C95967509 @default.
- W4220677977 hasConceptScore W4220677977C111670793 @default.
- W4220677977 hasConceptScore W4220677977C126322002 @default.