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- W4220679632 endingPage "101108" @default.
- W4220679632 startingPage "101108" @default.
- W4220679632 abstract "This review highlights the utility of applying concepts of temperament and personality traits in healthy individuals to functional studies of serotonin (5-hydroxytryptamine, 5-HT), in an effort to better elucidate the complex roles of 5-HT, and ultimately advance our understanding of psychopathology. We highlight empirical demonstrations of multifaceted and trait-dependent emotional and behavioural effects of manipulating 5-HT in humans, with emphasis on studies employing the technique of acute dietary tryptophan depletion, and additionally selective serotonin reuptake inhibitors. Relevant evidence from studies of 5-HT in non-human animals is also discussed. We show how the effects of central 5-HT manipulations affect behaviour depending not only upon situational context but also on pre-existing temperament and personality traits such as empathy, psychopathy, neuroticism, impulsivity, and intolerance of uncertainty. These effects can be related to the concept of the baseline (or rate-) dependency of neurochemical effects on behavioural control. We speculate about the neurochemical substrates for some of these trait-dependent effects, as well as their clinical significance." @default.
- W4220679632 created "2022-04-03" @default.
- W4220679632 creator A5040247083 @default.
- W4220679632 creator A5080762339 @default.
- W4220679632 creator A5085377096 @default.
- W4220679632 date "2022-06-01" @default.
- W4220679632 modified "2023-10-05" @default.
- W4220679632 title "Harnessing temperament to elucidate the complexities of serotonin function" @default.
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- W4220679632 doi "https://doi.org/10.1016/j.cobeha.2022.101108" @default.