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- W4220681645 abstract "Triple negative breast cancer (TNBC) remains a serious carcinoma threatening women's life. Natural compounds such as curcumin (CUR) have shown promising potential in TNBC therapy without conventional toxicity like chemotherapeutics. To improve the therapeutic efficiency, a pH/redox nanocarrier ([email protected] NPs) was developed for tumor specific delivery of CUR. [email protected] NPs showed good size distribution, encapsulation efficiency and stability under physiological conditions. Detachment of polyethylene glycol (PEG) facilitated cellular uptake of [email protected] NPs after exposure to extracellular tumor pH. Subsequently CUR was released due to the intracellular redox environment. Thereafter, released CUR could efficiently induce apoptosis and cycle arrest, and inhibit TNBC cells. We further verified the biodistribution and antitumor effects in vivo and the results showed that [email protected] NPs demonstrated high tumor specific accumulation and effectively suppressed tumor growth without noticeable toxicity." @default.
- W4220681645 created "2022-04-03" @default.
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- W4220681645 date "2022-05-01" @default.
- W4220681645 modified "2023-10-18" @default.
- W4220681645 title "Dual-responsive polypeptide nanoparticles attenuate tumor-associated stromal desmoplasia and anticancer through programmable dissociation" @default.
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- W4220681645 doi "https://doi.org/10.1016/j.biomaterials.2022.121469" @default.
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