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• W4220681712 endingPage "167" @default.
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• W4220681712 abstract "Photo-oxygenation has become an effective way to inhibit Alzheimer's β-amyloid protein (Aβ) fibrillogenesis, which involves oxidative modification of Aβ by photo-oxidants. However, limitations of the current photo-oxidants, such as low biocompatibility and low affinity for Aβ, hinder the progression of the photo-oxygenation strategy. Herein, using human serum albumins (HSA) with binding affinity for Aβ as a platform, we have fabricated HSA-stabilized gold nanoclusters ([email protected]) and further modified the [email protected] with ethylenediamine to create basified HSA (HSA-B)-stabilized AuNCs. The basified composite, [email protected], showed significantly higher potency on the inhibition of β-amyloid formation and capability of reactive oxidative species generation than [email protected] In addition to the inhibition effect, under near-infrared (NIR) laser irradiation, [email protected] generated singlet oxygen to oxygenate Aβ monomers, distinctly alleviating Aβ-mediated neurotoxicity at a low concentration. In vivo studies demonstrated that NIR-activated [email protected] promoted the lifespan extension of transgenic C. elegans strain CL2006 by decreasing the Aβ burden. This well-designed [email protected] integrates inhibition, Aβ targeting, and photo-oxygenation, providing new insights into the development of protein-based photo-oxidant against Alzheimer's β-amyloid. Alzheimer's disease (AD) has been threatening human health for more than 100 years. Recently, researchers have focused on inhibiting β-amyloid protein (Aβ) aggregation by exploring photo-excited biomaterials, which enable modulation of Aβ fibrillization with high spatiotemporal controllability. The present work demonstrates the fabrication of basified human serum albumins (HSA-B)-stabilized gold nanoclusters ([email protected]), and shows the potential of this near-infrared (NIR) laser-activated [email protected] as a photo-oxidant against Aβ aggregation by photo-oxygenation. Our work should open a new horizon in the design of protein-based photo-oxidant for treating AD in the future." @default.
• W4220681712 created "2022-04-03" @default.
• W4220681712 creator A5003759585 @default.
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• W4220681712 date "2022-05-01" @default.
• W4220681712 modified "2023-10-09" @default.
• W4220681712 title "Composite of gold nanoclusters and basified human serum albumin significantly boosts the inhibition of Alzheimer's β-amyloid by photo-oxygenation" @default.
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• W4220681712 doi "https://doi.org/10.1016/j.actbio.2022.03.019" @default.
• W4220681712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35301147" @default.
• W4220681712 hasPublicationYear "2022" @default.
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