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- W4220683057 endingPage "667" @default.
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- W4220683057 abstract "Breast cancer remains a leading cause of mortality among women worldwide. Brain metastases confer extremely poor prognosis due to a lack of understanding of their specific biology, unique physiologic and anatomic features of the brain, and limited treatment strategies. A major roadblock in advancing the treatment of breast cancer brain metastases (BCBM) is the scarcity of representative experimental preclinical models. Current models are predominantly based on the use of animal xenograft models with immortalized breast cancer cell lines that poorly capture the disease’s heterogeneity. Recent years have witnessed the development of patient-derived in vitro and in vivo breast cancer culturing systems that more closely recapitulate the biology from individual patients. These advances led to the development of modern patient-tissue-based experimental models for BCBM. The success of preclinical models is also based on the imaging technologies used to detect metastases. Advances in animal brain imaging, including cellular MRI and multimodality imaging, allow sensitive and specific detection of brain metastases and monitoring treatment responses. These imaging technologies, together with novel translational breast cancer models based on patient-derived cancer tissues, represent a unique opportunity to advance our understanding of brain metastases biology and develop novel treatment approaches. This review discusses the state-of-the-art knowledge in preclinical models of this disease." @default.
- W4220683057 created "2022-04-03" @default.
- W4220683057 creator A5001716985 @default.
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- W4220683057 creator A5049722633 @default.
- W4220683057 creator A5064154222 @default.
- W4220683057 creator A5087204964 @default.
- W4220683057 date "2022-03-13" @default.
- W4220683057 modified "2023-10-18" @default.
- W4220683057 title "Preclinical Models of Brain Metastases in Breast Cancer" @default.
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