Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220683610> ?p ?o ?g. }
- W4220683610 endingPage "121682" @default.
- W4220683610 startingPage "121682" @default.
- W4220683610 abstract "Glioblastoma multiforme (GBM) is the most common malignant brain cancer, characterized by high invasiveness and poor prognosis. Docetaxel (DTX) is a chemotherapeutic drug with promising anti-tumor properties. However, conventional intravenous formulations exhibit side effects of systemic biodistribution and low brain bioavailability, limiting their clinical use. The current work aimed to evaluate the effect of DTX-loaded nanostructured lipid carriers (NLC) functionalized with bevacizumab (BVZ-NLC-DTX) against GBM using in vitro and in vivo models. The NLC was obtained by the fusion-emulsification method followed by sonication, with narrow size distribution, negative zeta potential, and low polydispersity index. NLC showed DTX entrapment efficiency above 90%. BVZ coupling efficiency was 62% and BVZ integrity after functionalization was confirmed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Calorimetry studies confirmed thermal stability and molecular dispersion of DTX in the lipid matrix. NLC showed a sustained DTX release over 84 h. In vitro anti-tumor assays shown that BVZ-NLC-DTX selectively increased the cytotoxic of DTX in cells overexpressing VEGF (U87MG and A172), but not in peripheral blood mononuclear cells (PMBCs), promoting cell death by apoptosis. BVZ functionalization did not impair cellular uptake. An in vivo orthotopic rat model demonstrated that free-DTX was not capable of reducing tumor growth whereas BVZ-NLC-DTX reduced up to 70% tumor volume after 15-days of treatment. Therefore, this study contributes to understanding new nanotechnology-based vehicles capable of reaching the brain more efficiently and repurposing the use of anti-cancer drugs in GBM treatment." @default.
- W4220683610 created "2022-04-03" @default.
- W4220683610 creator A5004834220 @default.
- W4220683610 creator A5005334098 @default.
- W4220683610 creator A5008372630 @default.
- W4220683610 creator A5010905960 @default.
- W4220683610 creator A5015836766 @default.
- W4220683610 creator A5023033849 @default.
- W4220683610 creator A5025881155 @default.
- W4220683610 creator A5028072081 @default.
- W4220683610 creator A5039290025 @default.
- W4220683610 creator A5068540770 @default.
- W4220683610 creator A5075393288 @default.
- W4220683610 creator A5081767788 @default.
- W4220683610 creator A5082159028 @default.
- W4220683610 creator A5084163257 @default.
- W4220683610 date "2022-04-01" @default.
- W4220683610 modified "2023-10-17" @default.
- W4220683610 title "Glioblastoma multiforme targeted delivery of docetaxel using bevacizumab-modified nanostructured lipid carriers impair in vitro cell growth and in vivo tumor progression" @default.
- W4220683610 cites W1756165953 @default.
- W4220683610 cites W1963569255 @default.
- W4220683610 cites W1964432330 @default.
- W4220683610 cites W1971574874 @default.
- W4220683610 cites W1972840121 @default.
- W4220683610 cites W1973725909 @default.
- W4220683610 cites W1989392234 @default.
- W4220683610 cites W1990440588 @default.
- W4220683610 cites W2004563219 @default.
- W4220683610 cites W2009392213 @default.
- W4220683610 cites W2013430397 @default.
- W4220683610 cites W2029704253 @default.
- W4220683610 cites W2030747032 @default.
- W4220683610 cites W2032531096 @default.
- W4220683610 cites W2040555899 @default.
- W4220683610 cites W2043371238 @default.
- W4220683610 cites W2044898192 @default.
- W4220683610 cites W2055265206 @default.
- W4220683610 cites W2057030040 @default.
- W4220683610 cites W2064365810 @default.
- W4220683610 cites W2066864375 @default.
- W4220683610 cites W2068091371 @default.
- W4220683610 cites W2070518196 @default.
- W4220683610 cites W2071306094 @default.
- W4220683610 cites W2092451289 @default.
- W4220683610 cites W2094760556 @default.
- W4220683610 cites W2136390269 @default.
- W4220683610 cites W2143870632 @default.
- W4220683610 cites W2163241139 @default.
- W4220683610 cites W2165610118 @default.
- W4220683610 cites W2174258218 @default.
- W4220683610 cites W2439038862 @default.
- W4220683610 cites W2513929170 @default.
- W4220683610 cites W2523649430 @default.
- W4220683610 cites W2594099172 @default.
- W4220683610 cites W2596432151 @default.
- W4220683610 cites W2626868912 @default.
- W4220683610 cites W2743911010 @default.
- W4220683610 cites W2744658185 @default.
- W4220683610 cites W2750531506 @default.
- W4220683610 cites W2755751245 @default.
- W4220683610 cites W2756480854 @default.
- W4220683610 cites W2761517027 @default.
- W4220683610 cites W2770932522 @default.
- W4220683610 cites W2781098008 @default.
- W4220683610 cites W2783972162 @default.
- W4220683610 cites W2789539260 @default.
- W4220683610 cites W2793024240 @default.
- W4220683610 cites W2794838235 @default.
- W4220683610 cites W2806263720 @default.
- W4220683610 cites W2896506009 @default.
- W4220683610 cites W2907794764 @default.
- W4220683610 cites W2923862917 @default.
- W4220683610 cites W2944221734 @default.
- W4220683610 cites W2954338576 @default.
- W4220683610 cites W2965445824 @default.
- W4220683610 cites W2966752580 @default.
- W4220683610 cites W2968139886 @default.
- W4220683610 cites W2987049800 @default.
- W4220683610 cites W3006032423 @default.
- W4220683610 cites W3009898868 @default.
- W4220683610 cites W3011814292 @default.
- W4220683610 cites W3012817514 @default.
- W4220683610 cites W3021426480 @default.
- W4220683610 cites W3032377855 @default.
- W4220683610 cites W3048721204 @default.
- W4220683610 cites W3082839366 @default.
- W4220683610 cites W3096360222 @default.
- W4220683610 cites W3125536766 @default.
- W4220683610 cites W3136454776 @default.
- W4220683610 cites W3138174338 @default.
- W4220683610 cites W3156457863 @default.
- W4220683610 cites W3161025392 @default.
- W4220683610 cites W3163958853 @default.
- W4220683610 cites W3196752396 @default.
- W4220683610 cites W3198216827 @default.
- W4220683610 cites W4252748963 @default.
- W4220683610 doi "https://doi.org/10.1016/j.ijpharm.2022.121682" @default.
- W4220683610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35307470" @default.