FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220685915> ?p ?o ?g. }

• W4220685915 endingPage "2428" @default.
• W4220685915 startingPage "2419" @default.
• W4220685915 abstract "Interleukin-6 (IL-6) influences both inflammatory response and anti-inflammatory processes. This cytokine can be released by exercising skeletal muscle, which characterizes it as a myokine. Unlike what is observed in inflammation, IL-6 produced by skeletal muscle is not preceded by the release of other pro-inflammatory cytokines, but it seems to be dependent on the lactate produced during exercise, thus causing different effects from those seen in inflammatory state. After binding to its receptor, myokine IL-6 activates the PI3K-Akt pathway. One consequence of this upregulation is the potentiation of insulin signaling, which enhances insulin sensitivity. IL-6 increases GLUT-4 vesicle mobilization to the muscle cell periphery, increasing the glucose transport into the cell, and also glycogen synthesis. Muscle glycogen provides energy for ATP resynthesis, and regulates Ca2+ release by the sarcoplasmic reticulum, influencing muscle contraction, and, hence, muscle function by multiple pathways. Another implication for the upregulation of the PI3K-Akt pathway is the activation of mTORC1, which regulates mRNA translational efficiency by regulating translation machinery, and translational capacity by inducing ribosomal biogenesis. Thus, IL-6 may contribute to skeletal muscle hypertrophy and function by increasing contractile protein synthesis." @default.
• W4220685915 created "2022-04-03" @default.
• W4220685915 creator A5001989208 @default.
• W4220685915 creator A5044132798 @default.
• W4220685915 creator A5045997528 @default.
• W4220685915 date "2022-10-01" @default.
• W4220685915 modified "2023-10-17" @default.
• W4220685915 title "The Role of IL-6 Released During Exercise to Insulin Sensitivity and Muscle Hypertrophy" @default.
• W4220685915 cites W1524811105 @default.
• W4220685915 cites W1533291993 @default.
• W4220685915 cites W1595083713 @default.
• W4220685915 cites W1779691448 @default.
• W4220685915 cites W1895277992 @default.
• W4220685915 cites W1923443500 @default.
• W4220685915 cites W1968786460 @default.
• W4220685915 cites W1971739920 @default.
• W4220685915 cites W1972719386 @default.
• W4220685915 cites W1974081053 @default.
• W4220685915 cites W1975471112 @default.
• W4220685915 cites W1977169152 @default.
• W4220685915 cites W1981506281 @default.
• W4220685915 cites W1981885344 @default.
• W4220685915 cites W1983660080 @default.
• W4220685915 cites W1985754630 @default.
• W4220685915 cites W1990332775 @default.
• W4220685915 cites W1990960113 @default.
• W4220685915 cites W1993517337 @default.
• W4220685915 cites W1996032049 @default.
• W4220685915 cites W2006332285 @default.
• W4220685915 cites W2008410413 @default.
• W4220685915 cites W2009701222 @default.
• W4220685915 cites W2010763118 @default.
• W4220685915 cites W2016859011 @default.
• W4220685915 cites W2020430280 @default.
• W4220685915 cites W2020806581 @default.
• W4220685915 cites W2021469201 @default.
• W4220685915 cites W2025176940 @default.
• W4220685915 cites W2026681127 @default.
• W4220685915 cites W2027785297 @default.
• W4220685915 cites W2038123205 @default.
• W4220685915 cites W2041308494 @default.
• W4220685915 cites W2044346282 @default.
• W4220685915 cites W2058904982 @default.
• W4220685915 cites W2060607801 @default.
• W4220685915 cites W2069711307 @default.
• W4220685915 cites W2071249470 @default.
• W4220685915 cites W2072828191 @default.
• W4220685915 cites W2075511135 @default.
• W4220685915 cites W2077109432 @default.
• W4220685915 cites W2078669750 @default.
• W4220685915 cites W2084712051 @default.
• W4220685915 cites W2086528604 @default.
• W4220685915 cites W2087835012 @default.
• W4220685915 cites W2090843533 @default.
• W4220685915 cites W2096926851 @default.
• W4220685915 cites W2097210443 @default.
• W4220685915 cites W2100386453 @default.
• W4220685915 cites W2103488083 @default.
• W4220685915 cites W2106097347 @default.
• W4220685915 cites W2108778776 @default.
• W4220685915 cites W2109263914 @default.
• W4220685915 cites W2111074957 @default.
• W4220685915 cites W2111607026 @default.
• W4220685915 cites W2113737846 @default.
• W4220685915 cites W2115896420 @default.
• W4220685915 cites W2120934046 @default.
• W4220685915 cites W2121311831 @default.
• W4220685915 cites W2122481965 @default.
• W4220685915 cites W2124139079 @default.
• W4220685915 cites W2125543544 @default.
• W4220685915 cites W2130623329 @default.
• W4220685915 cites W2135821923 @default.
• W4220685915 cites W2136676465 @default.
• W4220685915 cites W2137383307 @default.
• W4220685915 cites W2138022955 @default.
• W4220685915 cites W2139406934 @default.
• W4220685915 cites W2146157811 @default.
• W4220685915 cites W2147235183 @default.
• W4220685915 cites W2150351516 @default.
• W4220685915 cites W2153133153 @default.
• W4220685915 cites W2155509873 @default.
• W4220685915 cites W2156185764 @default.
• W4220685915 cites W2157144047 @default.
• W4220685915 cites W2158302351 @default.
• W4220685915 cites W2158389310 @default.
• W4220685915 cites W2161594264 @default.
• W4220685915 cites W2162357955 @default.
• W4220685915 cites W2169292567 @default.
• W4220685915 cites W2169503869 @default.
• W4220685915 cites W2171756298 @default.
• W4220685915 cites W2175877453 @default.
• W4220685915 cites W2513728460 @default.
• W4220685915 cites W2572265768 @default.
• W4220685915 cites W2611360243 @default.
• W4220685915 cites W2741175738 @default.
• W4220685915 cites W2773300145 @default.
• W4220685915 cites W2903863947 @default.
• W4220685915 cites W2913322512 @default.

• next