FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220686136> ?p ?o ?g. }

• W4220686136 abstract "Steroid-induced osteonecrosis of femoral head (SONFH) is a serious complication of glucocorticoid overused. Recent evidence has demonstrated that circRNAs exert key pathophysiological roles in a variety of disease processes. However, the role of circRNA in SONFH remains largely unknown. The current study sought to evaluate how hsa_circ_0058122 affects SONFH in dexamethasone (DEX) treated human umbilical vein endothelial cells (HUVECs) model.RT-PCR was used to demonstrate the hsa_circ_0058122 expression level in Dex-treated HUVECs cells. The effects of hsa_circ_0058122 on HUVECs apoptosis were evaluated via overexpression plasmid and siRNA. Using dual-luciferase and fluorescence in situ hybridization assays, we demonstrated that hsa_circ_0058122 binds to miR-7974 thereby facilitating HUVECs apoptosis. Bioinformatics analysis and western blot were performed to confirm target genes of hsa-miR-7974.In our previous work, we revealed the top 20 elevated circRNAs in SONFH patients were hsa_circ_0010027, hsa_circ_0058115, hsa_circ_0010026, hsa_circ_0058839, hsa_circ_0056886, hsa_circ_0056885, hsa_circ_0058146, hsa_circ_0058105, hsa_circ_0058112, hsa_circ_0058143, hsa_circ_0058102, hsa_circ_0058090, hsa_circ_0075353, hsa_circ_0058126, hsa_circ_0058130, hsa_circ_0058140, hsa_circ_0058122, hsa_circ_0058123, hsa_circ_0058103, and hsa_circ_0058121. Among these, hsa_circ_0058122 was finally selected for further investigation. We found hsa_circ_0058122 expression was markedly elevated in Dex-treated HUVECs cells, and the Dex-mediated HUVEC apoptosis was impaired in hsa_circ_0058122-silenced cells and increased in hsa_circ_0058122-overexpressing cells. hsa_circ_0058122 competitively binds to hsa-miR-7974, which in turn interacts with insulin-like growth factor binding protein 5 (IGFBP5).hsa_circ_0058122/miR-7974/IGFBP5 was proposed to be a key regulatory pathway for SONFH. DEX treatment upregulated hsa_circ_0058122 expression in HUVECs, which sponged miR-7974, thereby increasing IGFBP5 expression, the hsa_circ_0058122/miR-7974/IGFBP5 axis contributed to the Dex-mediated apoptosis. These findings may identify novel targets for SONFH molecular therapy." @default.
• W4220686136 created "2022-04-03" @default.
• W4220686136 creator A5001623596 @default.
• W4220686136 creator A5002926155 @default.
• W4220686136 creator A5073216396 @default.
• W4220686136 creator A5082778169 @default.
• W4220686136 date "2022-03-11" @default.
• W4220686136 modified "2023-10-18" @default.
• W4220686136 title "hsa_circ_0058122 knockdown prevents steroid‐induced osteonecrosis of the femoral head by inhibiting human umbilical vein endothelial cells apoptosis via the miR‐7974/IGFBP5 axis" @default.
• W4220686136 cites W1828714917 @default.
• W4220686136 cites W1937931902 @default.
• W4220686136 cites W1996977411 @default.
• W4220686136 cites W2006345660 @default.
• W4220686136 cites W2018056446 @default.
• W4220686136 cites W2058835062 @default.
• W4220686136 cites W2064165694 @default.
• W4220686136 cites W2121682401 @default.
• W4220686136 cites W2134629862 @default.
• W4220686136 cites W2285751548 @default.
• W4220686136 cites W2302185643 @default.
• W4220686136 cites W2516096196 @default.
• W4220686136 cites W2566881606 @default.
• W4220686136 cites W2592988313 @default.
• W4220686136 cites W2600581473 @default.
• W4220686136 cites W2601436215 @default.
• W4220686136 cites W2613179596 @default.
• W4220686136 cites W2617715606 @default.
• W4220686136 cites W2752880228 @default.
• W4220686136 cites W2765658585 @default.
• W4220686136 cites W2784087245 @default.
• W4220686136 cites W2795078185 @default.
• W4220686136 cites W2806443711 @default.
• W4220686136 cites W2883062882 @default.
• W4220686136 cites W2888828322 @default.
• W4220686136 cites W2897729287 @default.
• W4220686136 cites W2897825874 @default.
• W4220686136 cites W2912017471 @default.
• W4220686136 cites W2914026182 @default.
• W4220686136 cites W2915433652 @default.
• W4220686136 cites W2942409680 @default.
• W4220686136 cites W2945262493 @default.
• W4220686136 cites W2964331590 @default.
• W4220686136 cites W2967043226 @default.
• W4220686136 cites W2970358232 @default.
• W4220686136 cites W2974612830 @default.
• W4220686136 cites W2980253985 @default.
• W4220686136 cites W2983642400 @default.
• W4220686136 cites W2999541095 @default.
• W4220686136 cites W3003662549 @default.
• W4220686136 cites W3003985683 @default.
• W4220686136 cites W3012539759 @default.
• W4220686136 cites W3025113122 @default.
• W4220686136 cites W3033079807 @default.
• W4220686136 cites W3115444289 @default.
• W4220686136 cites W3167860690 @default.
• W4220686136 cites W4220686136 @default.
• W4220686136 doi "https://doi.org/10.1002/jcla.24134" @default.
• W4220686136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35274778" @default.
• W4220686136 hasPublicationYear "2022" @default.
• W4220686136 type Work @default.
• W4220686136 citedByCount "1" @default.
• W4220686136 countsByYear W42206861362022 @default.
• W4220686136 crossrefType "journal-article" @default.
• W4220686136 hasAuthorship W4220686136A5001623596 @default.
• W4220686136 hasAuthorship W4220686136A5002926155 @default.
• W4220686136 hasAuthorship W4220686136A5073216396 @default.
• W4220686136 hasAuthorship W4220686136A5082778169 @default.
• W4220686136 hasBestOaLocation W42206861362 @default.
• W4220686136 hasConcept C104317684 @default.
• W4220686136 hasConcept C153911025 @default.
• W4220686136 hasConcept C173396325 @default.
• W4220686136 hasConcept C185592680 @default.
• W4220686136 hasConcept C190283241 @default.
• W4220686136 hasConcept C202751555 @default.
• W4220686136 hasConcept C2776415932 @default.
• W4220686136 hasConcept C2777411675 @default.
• W4220686136 hasConcept C55493867 @default.
• W4220686136 hasConcept C86803240 @default.
• W4220686136 hasConceptScore W4220686136C104317684 @default.
• W4220686136 hasConceptScore W4220686136C153911025 @default.
• W4220686136 hasConceptScore W4220686136C173396325 @default.
• W4220686136 hasConceptScore W4220686136C185592680 @default.
• W4220686136 hasConceptScore W4220686136C190283241 @default.
• W4220686136 hasConceptScore W4220686136C202751555 @default.
• W4220686136 hasConceptScore W4220686136C2776415932 @default.
• W4220686136 hasConceptScore W4220686136C2777411675 @default.
• W4220686136 hasConceptScore W4220686136C55493867 @default.
• W4220686136 hasConceptScore W4220686136C86803240 @default.
• W4220686136 hasIssue "4" @default.
• W4220686136 hasLocation W42206861361 @default.
• W4220686136 hasLocation W42206861362 @default.
• W4220686136 hasLocation W42206861363 @default.
• W4220686136 hasOpenAccess W4220686136 @default.
• W4220686136 hasPrimaryLocation W42206861361 @default.
• W4220686136 hasRelatedWork W2182530393 @default.
• W4220686136 hasRelatedWork W2367443652 @default.
• W4220686136 hasRelatedWork W2369756350 @default.
• W4220686136 hasRelatedWork W2371992350 @default.
• W4220686136 hasRelatedWork W2374957529 @default.
• W4220686136 hasRelatedWork W2391903354 @default.

• next