Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220686525> ?p ?o ?g. }
- W4220686525 abstract "Urokinase-type plasminogen activator receptor (uPAR) is an attractive target for the treatment of cancer, because it is expressed at low levels in healthy tissues but at high levels in malignant tumours. uPAR is closely related to the invasion and metastasis of malignant tumours, plays important roles in the degradation of extracellular matrix (ECM), tumour angiogenesis, cell proliferation and apoptosis, and is associated with the multidrug resistance (MDR) of tumour cells, which has important guiding significance for the judgement of tumor malignancy and prognosis. Several uPAR-targeted antitumour therapeutic agents have been developed to suppress tumour growth, metastatic processes and drug resistance. Here, we review the recent advances in the development of uPAR-targeted antitumor therapeutic strategies, including nanoplatforms carrying therapeutic agents, photodynamic therapy (PDT)/photothermal therapy (PTT) platforms, oncolytic virotherapy, gene therapy technologies, monoclonal antibody therapy and tumour immunotherapy, to promote the translation of these therapeutic agents to clinical applications." @default.
- W4220686525 created "2022-04-03" @default.
- W4220686525 creator A5001125162 @default.
- W4220686525 creator A5008769263 @default.
- W4220686525 creator A5029672049 @default.
- W4220686525 creator A5032835557 @default.
- W4220686525 creator A5047488004 @default.
- W4220686525 creator A5054254277 @default.
- W4220686525 creator A5080609124 @default.
- W4220686525 creator A5081147184 @default.
- W4220686525 creator A5087137381 @default.
- W4220686525 date "2022-03-18" @default.
- W4220686525 modified "2023-10-05" @default.
- W4220686525 title "Urokinase-type plasminogen activator receptor (uPAR) as a therapeutic target in cancer" @default.
- W4220686525 cites W1504344127 @default.
- W4220686525 cites W1536777249 @default.
- W4220686525 cites W1550055752 @default.
- W4220686525 cites W1572567571 @default.
- W4220686525 cites W1581591459 @default.
- W4220686525 cites W1596848781 @default.
- W4220686525 cites W1602232244 @default.
- W4220686525 cites W1604744894 @default.
- W4220686525 cites W1611413521 @default.
- W4220686525 cites W1618760884 @default.
- W4220686525 cites W1670322156 @default.
- W4220686525 cites W1823812337 @default.
- W4220686525 cites W1844163723 @default.
- W4220686525 cites W1870813039 @default.
- W4220686525 cites W1902790090 @default.
- W4220686525 cites W1913328895 @default.
- W4220686525 cites W1964386731 @default.
- W4220686525 cites W1964588019 @default.
- W4220686525 cites W1964732822 @default.
- W4220686525 cites W1965339253 @default.
- W4220686525 cites W1976479670 @default.
- W4220686525 cites W1977826373 @default.
- W4220686525 cites W1979327226 @default.
- W4220686525 cites W1980849091 @default.
- W4220686525 cites W1981674020 @default.
- W4220686525 cites W1982601372 @default.
- W4220686525 cites W1992197455 @default.
- W4220686525 cites W1995362315 @default.
- W4220686525 cites W1997437779 @default.
- W4220686525 cites W1999807011 @default.
- W4220686525 cites W2002072990 @default.
- W4220686525 cites W2002587153 @default.
- W4220686525 cites W2002672432 @default.
- W4220686525 cites W2003263309 @default.
- W4220686525 cites W2003844587 @default.
- W4220686525 cites W2011816149 @default.
- W4220686525 cites W2012532921 @default.
- W4220686525 cites W2012964979 @default.
- W4220686525 cites W2014418809 @default.
- W4220686525 cites W2015314629 @default.
- W4220686525 cites W2015824080 @default.
- W4220686525 cites W2018930320 @default.
- W4220686525 cites W2019021342 @default.
- W4220686525 cites W2019022249 @default.
- W4220686525 cites W2021080617 @default.
- W4220686525 cites W2024743028 @default.
- W4220686525 cites W2025569655 @default.
- W4220686525 cites W2025739511 @default.
- W4220686525 cites W2028153333 @default.
- W4220686525 cites W2031517790 @default.
- W4220686525 cites W2031689534 @default.
- W4220686525 cites W2033445130 @default.
- W4220686525 cites W2033466592 @default.
- W4220686525 cites W2033990975 @default.
- W4220686525 cites W2035103067 @default.
- W4220686525 cites W2035247318 @default.
- W4220686525 cites W2035971911 @default.
- W4220686525 cites W2036699952 @default.
- W4220686525 cites W2038054727 @default.
- W4220686525 cites W2039445887 @default.
- W4220686525 cites W2039469454 @default.
- W4220686525 cites W2039918907 @default.
- W4220686525 cites W2041455990 @default.
- W4220686525 cites W2045232127 @default.
- W4220686525 cites W2049182264 @default.
- W4220686525 cites W2049631846 @default.
- W4220686525 cites W2050232735 @default.
- W4220686525 cites W2050732886 @default.
- W4220686525 cites W2054214202 @default.
- W4220686525 cites W2055724402 @default.
- W4220686525 cites W2056146626 @default.
- W4220686525 cites W2056614490 @default.
- W4220686525 cites W2057938042 @default.
- W4220686525 cites W2059595214 @default.
- W4220686525 cites W2062370198 @default.
- W4220686525 cites W2063732036 @default.
- W4220686525 cites W2065236483 @default.
- W4220686525 cites W2065951704 @default.
- W4220686525 cites W2066085455 @default.
- W4220686525 cites W2068269053 @default.
- W4220686525 cites W2069846304 @default.
- W4220686525 cites W2069951758 @default.
- W4220686525 cites W2071242724 @default.
- W4220686525 cites W2072943902 @default.
- W4220686525 cites W2073485723 @default.
- W4220686525 cites W2073977669 @default.