Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220686761> ?p ?o ?g. }
- W4220686761 abstract "Agonistic CD27 monoclonal antibodies (mAb) have demonstrated impressive anti-tumour efficacy in multiple preclinical models but modest clinical responses. This might reflect current reagents delivering suboptimal CD27 agonism. Here, using a novel panel of CD27 mAb including a clinical candidate, we investigate the determinants of CD27 mAb agonism. Epitope mapping and in silico docking analysis show that mAb binding to membrane-distal and external-facing residues are stronger agonists. However, poor epitope-dependent agonism could partially be overcome by Fc-engineering, using mAb isotypes that promote receptor clustering, such as human immunoglobulin G1 (hIgG1, h1) with enhanced affinity to Fc gamma receptor (FcγR) IIb, or hIgG2 (h2). This study provides the critical knowledge required for the development of agonistic CD27 mAb that are potentially more clinically efficacious." @default.
- W4220686761 created "2022-04-03" @default.
- W4220686761 creator A5020755903 @default.
- W4220686761 creator A5027887577 @default.
- W4220686761 creator A5028006614 @default.
- W4220686761 creator A5028465682 @default.
- W4220686761 creator A5035396311 @default.
- W4220686761 creator A5049818256 @default.
- W4220686761 creator A5051479972 @default.
- W4220686761 creator A5056420151 @default.
- W4220686761 creator A5061182152 @default.
- W4220686761 creator A5067462254 @default.
- W4220686761 creator A5073058385 @default.
- W4220686761 creator A5076688601 @default.
- W4220686761 creator A5082666045 @default.
- W4220686761 creator A5086283627 @default.
- W4220686761 creator A5088427342 @default.
- W4220686761 date "2022-03-14" @default.
- W4220686761 modified "2023-10-14" @default.
- W4220686761 title "Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering" @default.
- W4220686761 cites W1550097974 @default.
- W4220686761 cites W1594509286 @default.
- W4220686761 cites W1865235773 @default.
- W4220686761 cites W1915689252 @default.
- W4220686761 cites W1982861708 @default.
- W4220686761 cites W1985266211 @default.
- W4220686761 cites W1991656907 @default.
- W4220686761 cites W1995926508 @default.
- W4220686761 cites W2007868209 @default.
- W4220686761 cites W2017873446 @default.
- W4220686761 cites W2021710291 @default.
- W4220686761 cites W2023776610 @default.
- W4220686761 cites W2024992774 @default.
- W4220686761 cites W2039038215 @default.
- W4220686761 cites W2048787440 @default.
- W4220686761 cites W2051995022 @default.
- W4220686761 cites W2057745345 @default.
- W4220686761 cites W2090770261 @default.
- W4220686761 cites W2097995306 @default.
- W4220686761 cites W2100612316 @default.
- W4220686761 cites W2101581360 @default.
- W4220686761 cites W2104088439 @default.
- W4220686761 cites W2109900474 @default.
- W4220686761 cites W2111110781 @default.
- W4220686761 cites W2115759102 @default.
- W4220686761 cites W2117281169 @default.
- W4220686761 cites W2121080857 @default.
- W4220686761 cites W2126489810 @default.
- W4220686761 cites W2146146606 @default.
- W4220686761 cites W2153777287 @default.
- W4220686761 cites W2154019529 @default.
- W4220686761 cites W2156353875 @default.
- W4220686761 cites W2162743871 @default.
- W4220686761 cites W2169189236 @default.
- W4220686761 cites W2169512053 @default.
- W4220686761 cites W2332839490 @default.
- W4220686761 cites W2380566153 @default.
- W4220686761 cites W2411733041 @default.
- W4220686761 cites W2474661075 @default.
- W4220686761 cites W2549757281 @default.
- W4220686761 cites W2572174216 @default.
- W4220686761 cites W2607901192 @default.
- W4220686761 cites W2611196568 @default.
- W4220686761 cites W2612746828 @default.
- W4220686761 cites W2767938018 @default.
- W4220686761 cites W2774420072 @default.
- W4220686761 cites W2785376969 @default.
- W4220686761 cites W2792557198 @default.
- W4220686761 cites W2794577178 @default.
- W4220686761 cites W2802801209 @default.
- W4220686761 cites W2889007771 @default.
- W4220686761 cites W2901938738 @default.
- W4220686761 cites W2936108326 @default.
- W4220686761 cites W2952779287 @default.
- W4220686761 cites W2977358098 @default.
- W4220686761 cites W2983012520 @default.
- W4220686761 cites W3021577750 @default.
- W4220686761 cites W3027871570 @default.
- W4220686761 cites W3081615360 @default.
- W4220686761 cites W3117480333 @default.
- W4220686761 cites W3175200872 @default.
- W4220686761 cites W3195452533 @default.
- W4220686761 cites W34501487 @default.
- W4220686761 cites W4239989216 @default.
- W4220686761 doi "https://doi.org/10.1038/s42003-022-03182-6" @default.
- W4220686761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35288635" @default.
- W4220686761 hasPublicationYear "2022" @default.
- W4220686761 type Work @default.
- W4220686761 citedByCount "6" @default.
- W4220686761 countsByYear W42206867612022 @default.
- W4220686761 countsByYear W42206867612023 @default.
- W4220686761 crossrefType "journal-article" @default.
- W4220686761 hasAuthorship W4220686761A5020755903 @default.
- W4220686761 hasAuthorship W4220686761A5027887577 @default.
- W4220686761 hasAuthorship W4220686761A5028006614 @default.
- W4220686761 hasAuthorship W4220686761A5028465682 @default.
- W4220686761 hasAuthorship W4220686761A5035396311 @default.
- W4220686761 hasAuthorship W4220686761A5049818256 @default.
- W4220686761 hasAuthorship W4220686761A5051479972 @default.
- W4220686761 hasAuthorship W4220686761A5056420151 @default.