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• W4220687536 abstract "We report here a new method for the synthesis of organohydrosilanes from phenols and ketones. This method is established through reductive C-Si coupling of chlorohydrosilanes via unconventional Si-Cl cleavage. The reaction offers access to aryl- and alkenylhydrosilanes with a scope that is complementary to those of the established methods. Electron-rich, electron-poor, and ortho-/meta-/para-substituted (hetero)aryl electrophiles, as well as cyclic and acyclic alkenyl electrophiles, were coupled successfully. Functionalities, including Grignard-sensitive groups (e.g., primary amine, amide, phenol, ketone, ester, and free indole), acid-sensitive groups (e.g., ketal and THP protection), alkyl-Cl, pyridine, furan, thiophene, Ar-Bpin, and Ar-SiMe3 , were tolerated. Gram-scale reaction, incorporation of -Si(H)R2 into complex biologically active molecules, and derivatization of formed organohydrosilanes are demonstrated." @default.
• W4220687536 created "2022-04-03" @default.
• W4220687536 creator A5008030471 @default.
• W4220687536 creator A5009932116 @default.
• W4220687536 creator A5023092001 @default.
• W4220687536 creator A5025891691 @default.
• W4220687536 creator A5036313933 @default.
• W4220687536 date "2022-03-21" @default.
• W4220687536 modified "2023-10-16" @default.
• W4220687536 title "Nickel‐Catalyzed Reductive C(sp ² )−Si Coupling of Chlorohydrosilanes via Si−Cl Cleavage" @default.
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• W4220687536 doi "https://doi.org/10.1002/anie.202200215" @default.
• W4220687536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35263015" @default.
• W4220687536 hasPublicationYear "2022" @default.
• W4220687536 type Work @default.

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