FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220687563> ?p ?o ?g. }

• W4220687563 abstract "SARS-CoV-2 virus requires host proteases to cleave its spike protein to bind to its ACE2 target through a two-step furin-mediated entry mechanism. Aprotinin is a broad-spectrum protease inhibitor that has been employed as antiviral drug for other human respiratory viruses. Also, it has important anti-inflammatory properties for inhibiting the innate immunity contact system.This was a multicentre, double-blind, randomized trial performed in four Spanish hospitals comparing standard treatment versus standard treatment + aprotinin for patients with COVID-19 between 20 May 2020 and 20 October 2021. The primary efficacy outcomes were length of hospital stay and ICU admission. The secondary endpoints were each of the primary efficacy outcomes and a composite of oxygen therapy, analytical parameters and death. Safety outcomes included adverse reactions to treatment during a 30-day follow-up period. Treatment was given for 11 days or till discharge.With almost identical analytical profiles, significant differences were observed in treatment time, which was 2 days lower in the aprotinin group (p = .002), and length of hospital admission, which was 5 days shorter in the aprotinin group (p = .003). The incidence of discharge was 2.19 times higher (HR: 2.188 [1.182-4.047]) in the aprotinin group than in the placebo group (p = .013). In addition, the aprotinin-treated group required less oxygen therapy and had no adverse reactions or side effects.Inhaled aprotinin may improve standard treatment and clinical outcomes in hospitalized patients with COVID-19, resulting in a shorter treatment time and hospitalization compared with the placebo group. The administration of aprotinin was safe." @default.
• W4220687563 created "2022-04-03" @default.
• W4220687563 creator A5001546228 @default.
• W4220687563 creator A5005575243 @default.
• W4220687563 creator A5011633823 @default.
• W4220687563 creator A5014060956 @default.
• W4220687563 creator A5014697391 @default.
• W4220687563 creator A5018269928 @default.
• W4220687563 creator A5019486245 @default.
• W4220687563 creator A5021915146 @default.
• W4220687563 creator A5026819512 @default.
• W4220687563 creator A5027211684 @default.
• W4220687563 creator A5029679467 @default.
• W4220687563 creator A5032873835 @default.
• W4220687563 creator A5034237995 @default.
• W4220687563 creator A5034288861 @default.
• W4220687563 creator A5035485102 @default.
• W4220687563 creator A5038982063 @default.
• W4220687563 creator A5039417833 @default.
• W4220687563 creator A5042282180 @default.
• W4220687563 creator A5042718389 @default.
• W4220687563 creator A5042802474 @default.
• W4220687563 creator A5048588652 @default.
• W4220687563 creator A5048723254 @default.
• W4220687563 creator A5048984321 @default.
• W4220687563 creator A5049586965 @default.
• W4220687563 creator A5050465849 @default.
• W4220687563 creator A5056009690 @default.
• W4220687563 creator A5062659757 @default.
• W4220687563 creator A5065232264 @default.
• W4220687563 creator A5066440832 @default.
• W4220687563 creator A5068926205 @default.
• W4220687563 creator A5070077105 @default.
• W4220687563 creator A5072627018 @default.
• W4220687563 creator A5078255845 @default.
• W4220687563 creator A5079088245 @default.
• W4220687563 creator A5080393195 @default.
• W4220687563 creator A5081153098 @default.
• W4220687563 creator A5083389235 @default.
• W4220687563 creator A5086399149 @default.
• W4220687563 creator A5088402906 @default.
• W4220687563 creator A5089377390 @default.
• W4220687563 date "2022-04-05" @default.
• W4220687563 modified "2023-10-01" @default.
• W4220687563 title "Aprotinin treatment against SARS‐CoV‐2: A randomized phase III study to evaluate the safety and efficacy of a pan‐protease inhibitor for moderate COVID‐19" @default.
• W4220687563 cites W1631047904 @default.
• W4220687563 cites W2007591654 @default.
• W4220687563 cites W2059629573 @default.
• W4220687563 cites W2085887280 @default.
• W4220687563 cites W2409085215 @default.
• W4220687563 cites W2412631254 @default.
• W4220687563 cites W2887942280 @default.
• W4220687563 cites W3005409321 @default.
• W4220687563 cites W3007866917 @default.
• W4220687563 cites W3011483298 @default.
• W4220687563 cites W3017302293 @default.
• W4220687563 cites W3019130299 @default.
• W4220687563 cites W3032031508 @default.
• W4220687563 cites W3035584582 @default.
• W4220687563 cites W3036107018 @default.
• W4220687563 cites W3037768701 @default.
• W4220687563 cites W3088048762 @default.
• W4220687563 cites W3094171379 @default.
• W4220687563 cites W3096621024 @default.
• W4220687563 cites W3097385142 @default.
• W4220687563 cites W3108305841 @default.
• W4220687563 cites W3111021405 @default.
• W4220687563 cites W3131609838 @default.
• W4220687563 cites W3132028487 @default.
• W4220687563 cites W3156990363 @default.
• W4220687563 cites W3173994157 @default.
• W4220687563 cites W3185947042 @default.
• W4220687563 cites W3187596458 @default.
• W4220687563 cites W3189646261 @default.
• W4220687563 cites W3197625569 @default.
• W4220687563 cites W3212262184 @default.
• W4220687563 cites W4200112411 @default.
• W4220687563 cites W4200559089 @default.
• W4220687563 cites W4210642183 @default.
• W4220687563 cites W4220687563 @default.
• W4220687563 cites W4225346184 @default.
• W4220687563 doi "https://doi.org/10.1111/eci.13776" @default.
• W4220687563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35342931" @default.
• W4220687563 hasPublicationYear "2022" @default.
• W4220687563 type Work @default.
• W4220687563 citedByCount "13" @default.
• W4220687563 countsByYear W42206875632022 @default.
• W4220687563 countsByYear W42206875632023 @default.
• W4220687563 crossrefType "journal-article" @default.
• W4220687563 hasAuthorship W4220687563A5001546228 @default.
• W4220687563 hasAuthorship W4220687563A5005575243 @default.
• W4220687563 hasAuthorship W4220687563A5011633823 @default.
• W4220687563 hasAuthorship W4220687563A5014060956 @default.
• W4220687563 hasAuthorship W4220687563A5014697391 @default.
• W4220687563 hasAuthorship W4220687563A5018269928 @default.
• W4220687563 hasAuthorship W4220687563A5019486245 @default.
• W4220687563 hasAuthorship W4220687563A5021915146 @default.
• W4220687563 hasAuthorship W4220687563A5026819512 @default.
• W4220687563 hasAuthorship W4220687563A5027211684 @default.
• W4220687563 hasAuthorship W4220687563A5029679467 @default.

• next