FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220687652> ?p ?o ?g. }

• W4220687652 abstract "An ideal protective vaccine against SARS-CoV-2 should not only be effective in preventing disease, but also in preventing virus transmission. It should also be well accepted by the population and have a simple logistic chain. To fulfill these criteria, we developed a thermostable, orally administered vaccine that can induce a robust mucosal neutralizing immune response. We used our platform based on retrovirus-derived enveloped virus-like particles (eVLPs) harnessed with variable surface proteins (VSPs) from the intestinal parasite Giardia lamblia, affording them resistance to degradation and the triggering of robust mucosal cellular and antibody immune responses after oral administration. We made eVLPs expressing various forms of the SARS-CoV-2 Spike protein (S), with or without membrane protein (M) expression. We found that prime-boost administration of VSP-decorated eVLPs expressing a pre-fusion stabilized form of S and M triggers robust mucosal responses against SARS-CoV-2 in mice and hamsters, which translate into complete protection from a viral challenge. Moreover, they dramatically boosted the IgA mucosal response of intramuscularly injected vaccines. We conclude that our thermostable orally administered eVLP vaccine could be a valuable addition to the current arsenal against SARS-CoV-2, in a stand-alone prime-boost vaccination strategy or as a boost for existing vaccines." @default.
• W4220687652 created "2022-04-03" @default.
• W4220687652 creator A5010638959 @default.
• W4220687652 creator A5018804650 @default.
• W4220687652 creator A5024877824 @default.
• W4220687652 creator A5044456322 @default.
• W4220687652 creator A5047578661 @default.
• W4220687652 creator A5086191612 @default.
• W4220687652 date "2022-02-25" @default.
• W4220687652 modified "2023-10-10" @default.
• W4220687652 title "A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity" @default.
• W4220687652 cites W1235838730 @default.
• W4220687652 cites W1659622831 @default.
• W4220687652 cites W1996472983 @default.
• W4220687652 cites W2001285947 @default.
• W4220687652 cites W2015245677 @default.
• W4220687652 cites W2035335384 @default.
• W4220687652 cites W2089866845 @default.
• W4220687652 cites W2092156843 @default.
• W4220687652 cites W2138541522 @default.
• W4220687652 cites W2143216598 @default.
• W4220687652 cites W2147024833 @default.
• W4220687652 cites W2166189758 @default.
• W4220687652 cites W2742418645 @default.
• W4220687652 cites W2910546747 @default.
• W4220687652 cites W2965115177 @default.
• W4220687652 cites W3007643904 @default.
• W4220687652 cites W3010539970 @default.
• W4220687652 cites W3013819977 @default.
• W4220687652 cites W3023376619 @default.
• W4220687652 cites W3024602798 @default.
• W4220687652 cites W3025320502 @default.
• W4220687652 cites W3036529319 @default.
• W4220687652 cites W3036887118 @default.
• W4220687652 cites W3039901154 @default.
• W4220687652 cites W3044914269 @default.
• W4220687652 cites W3045971896 @default.
• W4220687652 cites W3047159181 @default.
• W4220687652 cites W3048775784 @default.
• W4220687652 cites W3049654234 @default.
• W4220687652 cites W3085977120 @default.
• W4220687652 cites W3086603362 @default.
• W4220687652 cites W3087282910 @default.
• W4220687652 cites W3087402740 @default.
• W4220687652 cites W3088489318 @default.
• W4220687652 cites W3091814234 @default.
• W4220687652 cites W3093221919 @default.
• W4220687652 cites W3093768302 @default.
• W4220687652 cites W3093842248 @default.
• W4220687652 cites W3106737244 @default.
• W4220687652 cites W3112028440 @default.
• W4220687652 cites W3113774549 @default.
• W4220687652 cites W3119364446 @default.
• W4220687652 cites W3140400537 @default.
• W4220687652 cites W3164711393 @default.
• W4220687652 cites W3184249037 @default.
• W4220687652 cites W3186042928 @default.
• W4220687652 cites W3186891680 @default.
• W4220687652 doi "https://doi.org/10.3389/fimmu.2022.837443" @default.
• W4220687652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35281065" @default.
• W4220687652 hasPublicationYear "2022" @default.
• W4220687652 type Work @default.
• W4220687652 citedByCount "4" @default.
• W4220687652 countsByYear W42206876522022 @default.
• W4220687652 countsByYear W42206876522023 @default.
• W4220687652 crossrefType "journal-article" @default.
• W4220687652 hasAuthorship W4220687652A5010638959 @default.
• W4220687652 hasAuthorship W4220687652A5018804650 @default.
• W4220687652 hasAuthorship W4220687652A5024877824 @default.
• W4220687652 hasAuthorship W4220687652A5044456322 @default.
• W4220687652 hasAuthorship W4220687652A5047578661 @default.
• W4220687652 hasAuthorship W4220687652A5086191612 @default.
• W4220687652 hasBestOaLocation W42206876521 @default.
• W4220687652 hasConcept C159047783 @default.
• W4220687652 hasConcept C159654299 @default.
• W4220687652 hasConcept C203014093 @default.
• W4220687652 hasConcept C22070199 @default.
• W4220687652 hasConcept C2522874641 @default.
• W4220687652 hasConcept C2779341262 @default.
• W4220687652 hasConcept C2908647359 @default.
• W4220687652 hasConcept C71924100 @default.
• W4220687652 hasConcept C86803240 @default.
• W4220687652 hasConcept C8891405 @default.
• W4220687652 hasConcept C99454951 @default.
• W4220687652 hasConceptScore W4220687652C159047783 @default.
• W4220687652 hasConceptScore W4220687652C159654299 @default.
• W4220687652 hasConceptScore W4220687652C203014093 @default.
• W4220687652 hasConceptScore W4220687652C22070199 @default.
• W4220687652 hasConceptScore W4220687652C2522874641 @default.
• W4220687652 hasConceptScore W4220687652C2779341262 @default.
• W4220687652 hasConceptScore W4220687652C2908647359 @default.
• W4220687652 hasConceptScore W4220687652C71924100 @default.
• W4220687652 hasConceptScore W4220687652C86803240 @default.
• W4220687652 hasConceptScore W4220687652C8891405 @default.
• W4220687652 hasConceptScore W4220687652C99454951 @default.
• W4220687652 hasLocation W42206876521 @default.
• W4220687652 hasLocation W42206876522 @default.
• W4220687652 hasLocation W42206876523 @default.
• W4220687652 hasLocation W42206876524 @default.
• W4220687652 hasLocation W42206876525 @default.

• next