FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220687848> ?p ?o ?g. }

• W4220687848 endingPage "2048" @default.
• W4220687848 startingPage "2037" @default.
• W4220687848 abstract "Daily variations in cardiac electrophysiology and the incidence for different types of arrhythmias reflect ≈24 h changes in the environment, behaviour and internal circadian rhythms. This article focuses on studies that use animal models to separate the impact that circadian rhythms, as well as changes in the environment and behaviour, have on 24 h rhythms in heart rate and ventricular repolarization. Circadian rhythms are initiated at the cellular level by circadian clocks, transcription-translation feedback loops that cycle with a periodicity of 24 h. Several studies now show that the circadian clock in cardiomyocytes regulates the expression of cardiac ion channels by multiple mechanisms; underlies time-of-day changes in sinoatrial node excitability/intrinsic heart rate; and limits the duration of the ventricular action potential waveform. However, the 24 h rhythms in heart rate and ventricular repolarization are primarily driven by autonomic signalling. A functional role for the cardiomyocyte circadian clock appears to buffer the heart against perturbations. For example, the cardiomyocyte circadian clock limits QT-interval prolongation (especially at slower heart rates), and it may facilitate the realignment of the 24 h rhythm in heart rate to abrupt changes in the light cycle. Additional studies show that modifying rhythmic behaviours (including feeding behaviour) can dramatically impact the 24 h rhythms in heart rate and ventricular repolarization. If these mechanisms are conserved, these studies suggest that targeting endogenous circadian mechanisms in the heart, as well as modifying the timing of certain rhythmic behaviours, could emerge as therapeutic strategies to support heart function against perturbations and regulate 24 h rhythms in cardiac electrophysiology." @default.
• W4220687848 created "2022-04-03" @default.
• W4220687848 creator A5013571817 @default.
• W4220687848 creator A5013954157 @default.
• W4220687848 creator A5021755362 @default.
• W4220687848 creator A5022972976 @default.
• W4220687848 creator A5035365590 @default.
• W4220687848 creator A5068328556 @default.
• W4220687848 creator A5085574358 @default.
• W4220687848 date "2022-04-07" @default.
• W4220687848 modified "2023-10-01" @default.
• W4220687848 title "The role of the cardiomyocyte circadian clocks in ion channel regulation and cardiac electrophysiology" @default.
• W4220687848 cites W1494183442 @default.
• W4220687848 cites W160020775 @default.
• W4220687848 cites W1925652417 @default.
• W4220687848 cites W1990356805 @default.
• W4220687848 cites W1992726958 @default.
• W4220687848 cites W1993200978 @default.
• W4220687848 cites W1996679288 @default.
• W4220687848 cites W1996829258 @default.
• W4220687848 cites W2003302378 @default.
• W4220687848 cites W2009469595 @default.
• W4220687848 cites W2016081512 @default.
• W4220687848 cites W2024493318 @default.
• W4220687848 cites W2026095792 @default.
• W4220687848 cites W2027410128 @default.
• W4220687848 cites W2029582838 @default.
• W4220687848 cites W2031379791 @default.
• W4220687848 cites W2037124960 @default.
• W4220687848 cites W2037790601 @default.
• W4220687848 cites W2040340399 @default.
• W4220687848 cites W204059845 @default.
• W4220687848 cites W2043481283 @default.
• W4220687848 cites W2052336762 @default.
• W4220687848 cites W2066229820 @default.
• W4220687848 cites W2076778401 @default.
• W4220687848 cites W2080300476 @default.
• W4220687848 cites W2087466289 @default.
• W4220687848 cites W2112753502 @default.
• W4220687848 cites W2118727366 @default.
• W4220687848 cites W2121847288 @default.
• W4220687848 cites W2123789196 @default.
• W4220687848 cites W2124165250 @default.
• W4220687848 cites W2124582837 @default.
• W4220687848 cites W2133918896 @default.
• W4220687848 cites W2139372275 @default.
• W4220687848 cites W2151429542 @default.
• W4220687848 cites W2158611746 @default.
• W4220687848 cites W2162032228 @default.
• W4220687848 cites W2164824098 @default.
• W4220687848 cites W2168271199 @default.
• W4220687848 cites W2312696578 @default.
• W4220687848 cites W2336047942 @default.
• W4220687848 cites W2347113216 @default.
• W4220687848 cites W2400609677 @default.
• W4220687848 cites W2550188692 @default.
• W4220687848 cites W2560908995 @default.
• W4220687848 cites W2613480211 @default.
• W4220687848 cites W2751156346 @default.
• W4220687848 cites W2751175723 @default.
• W4220687848 cites W2807228974 @default.
• W4220687848 cites W2808964483 @default.
• W4220687848 cites W2916119357 @default.
• W4220687848 cites W2946975033 @default.
• W4220687848 cites W3011682897 @default.
• W4220687848 cites W3044525367 @default.
• W4220687848 cites W3103889497 @default.
• W4220687848 cites W3109123888 @default.
• W4220687848 cites W3112183567 @default.
• W4220687848 cites W3158978266 @default.
• W4220687848 cites W3174317442 @default.
• W4220687848 cites W3177446507 @default.
• W4220687848 cites W3197270704 @default.
• W4220687848 cites W3202004322 @default.
• W4220687848 cites W3205703818 @default.
• W4220687848 cites W3208055190 @default.
• W4220687848 cites W3208500832 @default.
• W4220687848 cites W4200462801 @default.
• W4220687848 doi "https://doi.org/10.1113/jp282402" @default.
• W4220687848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35301719" @default.
• W4220687848 hasPublicationYear "2022" @default.
• W4220687848 type Work @default.
• W4220687848 citedByCount "7" @default.
• W4220687848 countsByYear W42206878482022 @default.
• W4220687848 countsByYear W42206878482023 @default.
• W4220687848 crossrefType "journal-article" @default.
• W4220687848 hasAuthorship W4220687848A5013571817 @default.
• W4220687848 hasAuthorship W4220687848A5013954157 @default.
• W4220687848 hasAuthorship W4220687848A5021755362 @default.
• W4220687848 hasAuthorship W4220687848A5022972976 @default.
• W4220687848 hasAuthorship W4220687848A5035365590 @default.
• W4220687848 hasAuthorship W4220687848A5068328556 @default.
• W4220687848 hasAuthorship W4220687848A5085574358 @default.
• W4220687848 hasBestOaLocation W42206878481 @default.
• W4220687848 hasConcept C121446783 @default.
• W4220687848 hasConcept C126322002 @default.
• W4220687848 hasConcept C130679736 @default.
• W4220687848 hasConcept C134018914 @default.

• next