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- W4220688332 startingPage "188719" @default.
- W4220688332 abstract "Gastric cancer is globally the fourth leading cause of cancer-related deaths. Patients with diffuse-type gastric cancer (DGC) particularly have a poor prognosis that only marginally improved over the last decades, as conventional chemotherapies are frequently ineffective and specific therapies are unavailable. Early-stage DGC is characterized by intramucosal lesions of discohesive cells, which can be present for many years before the emergence of advanced DGC consisting of highly proliferative and invasive cells. The mechanisms underlying the key steps of DGC development and transition to aggressive tumors are starting to emerge. Novel mouse and organoid models for DGC, together with multi-omic analyses of DGC tumors, revealed contributions of both tumor cell-intrinsic alterations and gradual changes in the tumor microenvironment to DGC progression. In this review, we will discuss how these recent findings are leading towards an understanding of the cellular and molecular mechanisms responsible for DGC initiation and malignancy, which may provide opportunities for targeted therapies." @default.
- W4220688332 created "2022-04-03" @default.
- W4220688332 creator A5015453708 @default.
- W4220688332 creator A5024569067 @default.
- W4220688332 creator A5081274467 @default.
- W4220688332 creator A5084926314 @default.
- W4220688332 date "2022-05-01" @default.
- W4220688332 modified "2023-10-01" @default.
- W4220688332 title "Diffuse gastric cancer: Emerging mechanisms of tumor initiation and progression" @default.
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