Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220688399> ?p ?o ?g. }
- W4220688399 endingPage "17" @default.
- W4220688399 startingPage "1" @default.
- W4220688399 abstract "Hepatobiliary diseases and their complications cause the accumulation of toxic bile acids (BA) in the liver, blood, and other tissues, which may exacerbate the underlying condition and lead to unfavorable prognosis. To develop and validate prognostic biomarkers for the prediction of complications of cholestatic liver disease based on urinary BA indices, liquid chromatography-tandem mass spectrometry was used to analyze urine samples from 257 patients with cholestatic liver diseases during a 7-year follow-up period. The urinary BA profile and non-BA parameters were monitored, and logistic regression models were used to predict the prognosis of hepatobiliary disease-related complications. Urinary BA indices were applied to quantify the composition, metabolism, hydrophilicity, and toxicity of the BA profile. We have developed and validated the bile-acid liver disease complication (BALDC) model based on BA indices using logistic regression model, to predict the prognosis of cholestatic liver disease complications including ascites. The mixed BA and non-BA model was the most accurate and provided higher area under the receiver operating characteristic (ROC) and smaller akaike information criterion (AIC) values compared to both non-BA and MELD (models for end stage liver disease) models. Therefore, the mixed BA and non-BA model could be used to predict the development of ascites in patients diagnosed with liver disease at early stages of intervention. This will help physicians to make a better decision when treating hepatobiliary disease-related ascites." @default.
- W4220688399 created "2022-04-03" @default.
- W4220688399 creator A5021809794 @default.
- W4220688399 creator A5032785568 @default.
- W4220688399 creator A5035613509 @default.
- W4220688399 creator A5048901699 @default.
- W4220688399 creator A5068510005 @default.
- W4220688399 creator A5080342283 @default.
- W4220688399 creator A5085923829 @default.
- W4220688399 creator A5091162315 @default.
- W4220688399 date "2022-03-30" @default.
- W4220688399 modified "2023-10-14" @default.
- W4220688399 title "Urinary BA Indices as Prognostic Biomarkers for Complications Associated with Liver Diseases" @default.
- W4220688399 cites W1517943720 @default.
- W4220688399 cites W1876112410 @default.
- W4220688399 cites W1909800943 @default.
- W4220688399 cites W1964051982 @default.
- W4220688399 cites W1966620940 @default.
- W4220688399 cites W1975532829 @default.
- W4220688399 cites W1979124801 @default.
- W4220688399 cites W1982260172 @default.
- W4220688399 cites W1996559176 @default.
- W4220688399 cites W1999395169 @default.
- W4220688399 cites W2001137775 @default.
- W4220688399 cites W2004147962 @default.
- W4220688399 cites W2011237391 @default.
- W4220688399 cites W2011398201 @default.
- W4220688399 cites W2017557941 @default.
- W4220688399 cites W2017806914 @default.
- W4220688399 cites W2018853255 @default.
- W4220688399 cites W2024000207 @default.
- W4220688399 cites W2027860872 @default.
- W4220688399 cites W2031181423 @default.
- W4220688399 cites W2031762491 @default.
- W4220688399 cites W2042695038 @default.
- W4220688399 cites W2045084781 @default.
- W4220688399 cites W2047718984 @default.
- W4220688399 cites W2063744431 @default.
- W4220688399 cites W2083469788 @default.
- W4220688399 cites W2084314432 @default.
- W4220688399 cites W2088032711 @default.
- W4220688399 cites W2088136673 @default.
- W4220688399 cites W2089037922 @default.
- W4220688399 cites W2093282138 @default.
- W4220688399 cites W2105530267 @default.
- W4220688399 cites W2111641487 @default.
- W4220688399 cites W2115692333 @default.
- W4220688399 cites W2117099922 @default.
- W4220688399 cites W2127567473 @default.
- W4220688399 cites W2130880838 @default.
- W4220688399 cites W2133074258 @default.
- W4220688399 cites W2139693525 @default.
- W4220688399 cites W2140396673 @default.
- W4220688399 cites W2140666615 @default.
- W4220688399 cites W2148899675 @default.
- W4220688399 cites W2155890063 @default.
- W4220688399 cites W2157394313 @default.
- W4220688399 cites W2158196600 @default.
- W4220688399 cites W2162888435 @default.
- W4220688399 cites W2166972699 @default.
- W4220688399 cites W2171795832 @default.
- W4220688399 cites W2173648481 @default.
- W4220688399 cites W2412692934 @default.
- W4220688399 cites W2476846859 @default.
- W4220688399 cites W2484481405 @default.
- W4220688399 cites W2755334850 @default.
- W4220688399 cites W2780780868 @default.
- W4220688399 cites W2793943052 @default.
- W4220688399 cites W2803737839 @default.
- W4220688399 cites W2806321658 @default.
- W4220688399 cites W2953732988 @default.
- W4220688399 cites W3031233994 @default.
- W4220688399 cites W3133858114 @default.
- W4220688399 cites W3153805635 @default.
- W4220688399 cites W3165435133 @default.
- W4220688399 cites W3174905293 @default.
- W4220688399 cites W3199944319 @default.
- W4220688399 cites W379263722 @default.
- W4220688399 cites W4210986718 @default.
- W4220688399 cites W4211110117 @default.
- W4220688399 cites W4221024512 @default.
- W4220688399 cites W4225275327 @default.
- W4220688399 cites W4232006079 @default.
- W4220688399 cites W4255387568 @default.
- W4220688399 cites W4285719527 @default.
- W4220688399 doi "https://doi.org/10.1155/2022/5473752" @default.
- W4220688399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35402050" @default.
- W4220688399 hasPublicationYear "2022" @default.
- W4220688399 type Work @default.
- W4220688399 citedByCount "0" @default.
- W4220688399 crossrefType "journal-article" @default.
- W4220688399 hasAuthorship W4220688399A5021809794 @default.
- W4220688399 hasAuthorship W4220688399A5032785568 @default.
- W4220688399 hasAuthorship W4220688399A5035613509 @default.
- W4220688399 hasAuthorship W4220688399A5048901699 @default.
- W4220688399 hasAuthorship W4220688399A5068510005 @default.
- W4220688399 hasAuthorship W4220688399A5080342283 @default.
- W4220688399 hasAuthorship W4220688399A5085923829 @default.