Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220688546> ?p ?o ?g. }
- W4220688546 abstract "Abstract Functional analysis of high throughput experiments using pathway analysis is now ubiquitous. Though powerful, these methods often produce thousands of redundant results owing to knowledgebase redundancies upstream. This scale of results hinders extensive exploration by biologists and often leads to investigator biases due to previous knowledge and expectations. To address this issue, we present vissE, a flexible network-based analysis method that summarises redundancies into biological themes and provides various analytical modules to characterise and visualise them with respect to the underlying data, thus providing a comprehensive view of the biological system. We demonstrate vissE’s versatility by applying it to three different technologies: bulk, single-cell and spatial transcriptomics. Applying vissE to a factor analysis of a breast cancer spatial transcriptomic data, we identified stromal phenotypes that support tumour dissemination. Its adaptability allows vissE to enhance all existing gene-set enrichment and pathway analysis workflows, removing investigator bias from molecular discovery. Abstract Figure" @default.
- W4220688546 created "2022-04-03" @default.
- W4220688546 creator A5007306514 @default.
- W4220688546 creator A5018252802 @default.
- W4220688546 creator A5028078153 @default.
- W4220688546 creator A5032063587 @default.
- W4220688546 creator A5038054571 @default.
- W4220688546 creator A5063863213 @default.
- W4220688546 creator A5071339229 @default.
- W4220688546 creator A5087978393 @default.
- W4220688546 creator A5088957393 @default.
- W4220688546 date "2022-03-07" @default.
- W4220688546 modified "2023-09-30" @default.
- W4220688546 title "vissE: A versatile tool to identify and visualise higher-order molecular phenotypes from functional enrichment analysis" @default.
- W4220688546 cites W1562973462 @default.
- W4220688546 cites W1969353942 @default.
- W4220688546 cites W1995683190 @default.
- W4220688546 cites W2010327215 @default.
- W4220688546 cites W2013515157 @default.
- W4220688546 cites W2022945065 @default.
- W4220688546 cites W2024315189 @default.
- W4220688546 cites W2025855398 @default.
- W4220688546 cites W2035618305 @default.
- W4220688546 cites W2045729458 @default.
- W4220688546 cites W2056044063 @default.
- W4220688546 cites W2084168100 @default.
- W4220688546 cites W2097948046 @default.
- W4220688546 cites W2100980426 @default.
- W4220688546 cites W2103017472 @default.
- W4220688546 cites W2107018762 @default.
- W4220688546 cites W2110905563 @default.
- W4220688546 cites W2114104545 @default.
- W4220688546 cites W2120024428 @default.
- W4220688546 cites W2121280864 @default.
- W4220688546 cites W2130410032 @default.
- W4220688546 cites W2133465414 @default.
- W4220688546 cites W2134477837 @default.
- W4220688546 cites W2138207763 @default.
- W4220688546 cites W2138255346 @default.
- W4220688546 cites W2143947098 @default.
- W4220688546 cites W2144907278 @default.
- W4220688546 cites W2151572058 @default.
- W4220688546 cites W2169589032 @default.
- W4220688546 cites W2171030481 @default.
- W4220688546 cites W2171437346 @default.
- W4220688546 cites W2214074259 @default.
- W4220688546 cites W2466314544 @default.
- W4220688546 cites W2540833380 @default.
- W4220688546 cites W2606062902 @default.
- W4220688546 cites W2756978353 @default.
- W4220688546 cites W2774736917 @default.
- W4220688546 cites W2783018806 @default.
- W4220688546 cites W2868772566 @default.
- W4220688546 cites W2888939561 @default.
- W4220688546 cites W2900032527 @default.
- W4220688546 cites W2901068426 @default.
- W4220688546 cites W2907514116 @default.
- W4220688546 cites W2910111050 @default.
- W4220688546 cites W2912405236 @default.
- W4220688546 cites W2928665623 @default.
- W4220688546 cites W2947925171 @default.
- W4220688546 cites W2949177718 @default.
- W4220688546 cites W2967538289 @default.
- W4220688546 cites W2994535290 @default.
- W4220688546 cites W3003058300 @default.
- W4220688546 cites W3015459088 @default.
- W4220688546 cites W3036137852 @default.
- W4220688546 cites W3036895040 @default.
- W4220688546 cites W3090990034 @default.
- W4220688546 cites W3092495933 @default.
- W4220688546 cites W3095104045 @default.
- W4220688546 cites W3104267360 @default.
- W4220688546 cites W3129476455 @default.
- W4220688546 cites W3134165232 @default.
- W4220688546 cites W3158950527 @default.
- W4220688546 cites W3158998710 @default.
- W4220688546 cites W3164271582 @default.
- W4220688546 cites W3175752499 @default.
- W4220688546 cites W4233698560 @default.
- W4220688546 cites W4238308465 @default.
- W4220688546 doi "https://doi.org/10.1101/2022.03.06.483195" @default.
- W4220688546 hasPublicationYear "2022" @default.
- W4220688546 type Work @default.
- W4220688546 citedByCount "3" @default.
- W4220688546 countsByYear W42206885462022 @default.
- W4220688546 countsByYear W42206885462023 @default.
- W4220688546 crossrefType "posted-content" @default.
- W4220688546 hasAuthorship W4220688546A5007306514 @default.
- W4220688546 hasAuthorship W4220688546A5018252802 @default.
- W4220688546 hasAuthorship W4220688546A5028078153 @default.
- W4220688546 hasAuthorship W4220688546A5032063587 @default.
- W4220688546 hasAuthorship W4220688546A5038054571 @default.
- W4220688546 hasAuthorship W4220688546A5063863213 @default.
- W4220688546 hasAuthorship W4220688546A5071339229 @default.
- W4220688546 hasAuthorship W4220688546A5087978393 @default.
- W4220688546 hasAuthorship W4220688546A5088957393 @default.
- W4220688546 hasBestOaLocation W42206885461 @default.
- W4220688546 hasConcept C124101348 @default.
- W4220688546 hasConcept C177212765 @default.
- W4220688546 hasConcept C177264268 @default.