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• W4220688756 abstract "The water-soluble polysaccharide LBP-1 was isolated and characterized from Lycium barbarum L. LBP-1 was mainly composed of arabinose, galactose, glucose, xylose, mannose at a molar ratio of 37.53: 28.08: 14.72: 7.83: 4.50, respectively. Based on nuclear magnetic resonance (NMR) and methylation analysis, the backbone of LBP-1 was speculated in the α-L-Ara(1→[5-α-L-Ara(1 → 3)-β-D-Galp-(1→]n→4)-α-D-Galp-(1[→5-α-L-Ara (1]n [→6)-β-D-Galp-(1 → 4)-β-D-Galp-(1→]n, and the side chains of LBP-1 were in the α-L-Ara(1 → 3)-β-D-Galp-(1 → 6 position. These results showed that LBP-1 inhibited the growth of cancer A549 cells through cell cycle arrest and apoptosis, with an IC50 value of 42.5 μg/mL. In addition, LBP-1 altered the expression of Cyclin D1, Cyclin D3, and CDK 2, thus blocking the cell cycle in G0/G1 phase, reducing cell migration, and regulating the PI3K/Akt/mTOR signaling pathway to induce apoptosis." @default.
• W4220688756 created "2022-04-03" @default.
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• W4220688756 date "2022-06-01" @default.
• W4220688756 modified "2023-10-15" @default.
• W4220688756 title "Mechanism regulating the inhibition of lung cancer A549 cell proliferation and structural analysis of the polysaccharide Lycium barbarum" @default.
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• W4220688756 doi "https://doi.org/10.1016/j.fbio.2022.101664" @default.
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