FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220691872> ?p ?o ?g. }

• W4220691872 abstract "Osteoarticular tuberculosis is one of the extrapulmonary tuberculosis, which is mainly caused by direct infection of Mycobacterium tuberculosis or secondary infection of tuberculosis in other parts. Due to the low specificity of the current detection method, it is leading to a high misdiagnosis rate and subsequently affecting the follow-up treatment and prognosis. Metabolomics is mainly used to study the changes of the body's metabolites in different states, so it can serve as an important means in the discovery of disease-related metabolic biomarkers and the corresponding mechanism research. Liquid chromatography tandem mass spectrometry (LC-MS/MS) was used to detect and analyze metabolites in the serum with osteoarticular tuberculosis patients, disease controls, and healthy controls to find novel metabolic biomarkers that could be used in the diagnosis of osteoarticular tuberculosis. Our results showed that 68 differential metabolites (p<0.05, fold change>1.0) were obtained in osteoarticular tuberculosis serum after statistical analysis. Then, through the evaluation of diagnostic efficacy, PC[o-16:1(9Z)/18:0], PC[20:4(8Z,11Z,14Z,17Z)/18:0], PC[18:0/22:5(4Z,7Z,10Z,13Z,16Z)], SM(d18:1/20:0), and SM[d18:1/18:1(11Z)] were found as potential biomarkers with high diagnostic efficacy. Using bioinformatics analysis, we further found that these metabolites share many lipid metabolic signaling pathways, such as choline metabolism, sphingolipid signaling, retrograde endocannabinoid signaling, and sphingolipid and glycerophospholipid metabolism; these results suggest that lipid metabolism plays an important role in the pathological process of tuberculosis. This study can provide certain reference value for the study of metabolic biomarkers of osteoarticular tuberculosis and the mechanism of lipid metabolism in osteoarticular tuberculosis and even other tuberculosis diseases." @default.
• W4220691872 created "2022-04-03" @default.
• W4220691872 creator A5045963921 @default.
• W4220691872 creator A5067985443 @default.
• W4220691872 creator A5076924695 @default.
• W4220691872 creator A5090188924 @default.
• W4220691872 date "2022-03-25" @default.
• W4220691872 modified "2023-10-18" @default.
• W4220691872 title "Novel Potential Diagnostic Serum Biomarkers of Metabolomics in Osteoarticular Tuberculosis Patients: A Preliminary Study" @default.
• W4220691872 cites W1884885884 @default.
• W4220691872 cites W1970133720 @default.
• W4220691872 cites W1972805278 @default.
• W4220691872 cites W1983806465 @default.
• W4220691872 cites W2014438278 @default.
• W4220691872 cites W2044648227 @default.
• W4220691872 cites W2070570968 @default.
• W4220691872 cites W2081288755 @default.
• W4220691872 cites W2090707513 @default.
• W4220691872 cites W2102189561 @default.
• W4220691872 cites W2111793469 @default.
• W4220691872 cites W2112525893 @default.
• W4220691872 cites W2113468195 @default.
• W4220691872 cites W2128471563 @default.
• W4220691872 cites W2139723992 @default.
• W4220691872 cites W2144192914 @default.
• W4220691872 cites W2166061194 @default.
• W4220691872 cites W2478985445 @default.
• W4220691872 cites W2573842137 @default.
• W4220691872 cites W2578080472 @default.
• W4220691872 cites W2582913822 @default.
• W4220691872 cites W2766231415 @default.
• W4220691872 cites W2791421665 @default.
• W4220691872 cites W2792213513 @default.
• W4220691872 cites W2800468419 @default.
• W4220691872 cites W2802012939 @default.
• W4220691872 cites W2808827140 @default.
• W4220691872 cites W2883397463 @default.
• W4220691872 cites W2890425265 @default.
• W4220691872 cites W2900073858 @default.
• W4220691872 cites W2901636549 @default.
• W4220691872 cites W2909794724 @default.
• W4220691872 cites W2951732226 @default.
• W4220691872 cites W2953124793 @default.
• W4220691872 cites W2994941462 @default.
• W4220691872 cites W3000938352 @default.
• W4220691872 cites W3005935100 @default.
• W4220691872 cites W3010197702 @default.
• W4220691872 cites W3032278446 @default.
• W4220691872 cites W3043141786 @default.
• W4220691872 cites W3088904334 @default.
• W4220691872 cites W3098363553 @default.
• W4220691872 cites W3102002814 @default.
• W4220691872 cites W3115246131 @default.
• W4220691872 cites W3123200959 @default.
• W4220691872 cites W3131407320 @default.
• W4220691872 cites W2885368921 @default.
• W4220691872 doi "https://doi.org/10.3389/fcimb.2022.827528" @default.
• W4220691872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35402287" @default.
• W4220691872 hasPublicationYear "2022" @default.
• W4220691872 type Work @default.
• W4220691872 citedByCount "3" @default.
• W4220691872 countsByYear W42206918722023 @default.
• W4220691872 crossrefType "journal-article" @default.
• W4220691872 hasAuthorship W4220691872A5045963921 @default.
• W4220691872 hasAuthorship W4220691872A5067985443 @default.
• W4220691872 hasAuthorship W4220691872A5076924695 @default.
• W4220691872 hasAuthorship W4220691872A5090188924 @default.
• W4220691872 hasBestOaLocation W42206918721 @default.
• W4220691872 hasConcept C126322002 @default.
• W4220691872 hasConcept C135870905 @default.
• W4220691872 hasConcept C142724271 @default.
• W4220691872 hasConcept C192989942 @default.
• W4220691872 hasConcept C203014093 @default.
• W4220691872 hasConcept C21565614 @default.
• W4220691872 hasConcept C2776952329 @default.
• W4220691872 hasConcept C2777975735 @default.
• W4220691872 hasConcept C2778918659 @default.
• W4220691872 hasConcept C2779134260 @default.
• W4220691872 hasConcept C2781069245 @default.
• W4220691872 hasConcept C41625074 @default.
• W4220691872 hasConcept C4733338 @default.
• W4220691872 hasConcept C55493867 @default.
• W4220691872 hasConcept C60644358 @default.
• W4220691872 hasConcept C61705674 @default.
• W4220691872 hasConcept C62231903 @default.
• W4220691872 hasConcept C71924100 @default.
• W4220691872 hasConcept C86803240 @default.
• W4220691872 hasConcept C98274493 @default.
• W4220691872 hasConceptScore W4220691872C126322002 @default.
• W4220691872 hasConceptScore W4220691872C135870905 @default.
• W4220691872 hasConceptScore W4220691872C142724271 @default.
• W4220691872 hasConceptScore W4220691872C192989942 @default.
• W4220691872 hasConceptScore W4220691872C203014093 @default.
• W4220691872 hasConceptScore W4220691872C21565614 @default.
• W4220691872 hasConceptScore W4220691872C2776952329 @default.
• W4220691872 hasConceptScore W4220691872C2777975735 @default.
• W4220691872 hasConceptScore W4220691872C2778918659 @default.
• W4220691872 hasConceptScore W4220691872C2779134260 @default.
• W4220691872 hasConceptScore W4220691872C2781069245 @default.
• W4220691872 hasConceptScore W4220691872C41625074 @default.

• next