FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220693419> ?p ?o ?g. }

• W4220693419 abstract "Abstract Rapid advances in synthetic biology are driving the development of genetically engineered microbes as therapeutic agents for a multitude of human diseases, including cancer. The immunosuppressive microenvironment of solid tumors, in particular, creates a favorable niche for systemically administered bacteria to engraft and release therapeutic payloads. However, such payloads can be harmful if released outside the tumor in healthy tissues where the bacteria also engraft in smaller numbers. To address this limitation, we engineer therapeutic bacteria to be controlled by focused ultrasound, a form of energy that can be applied noninvasively to specific anatomical sites such as solid tumors. This control is provided by a temperature-actuated genetic state switch that produces lasting therapeutic output in response to briefly applied focused ultrasound hyperthermia. Using a combination of rational design and high-throughput screening we optimize the switching circuits of engineered cells and connect their activity to the release of immune checkpoint inhibitors. In a clinically relevant cancer model, ultrasound-activated therapeutic microbes successfully turn on in situ and induce a marked suppression of tumor growth. This technology provides a critical tool for the spatiotemporal targeting of potent bacterial therapeutics in a variety of biological and clinical scenarios." @default.
• W4220693419 created "2022-04-03" @default.
• W4220693419 creator A5029086218 @default.
• W4220693419 creator A5039944206 @default.
• W4220693419 creator A5042395452 @default.
• W4220693419 creator A5043009664 @default.
• W4220693419 creator A5046728930 @default.
• W4220693419 creator A5051459907 @default.
• W4220693419 creator A5057282120 @default.
• W4220693419 creator A5080586089 @default.
• W4220693419 creator A5090664557 @default.
• W4220693419 date "2022-03-24" @default.
• W4220693419 modified "2023-10-15" @default.
• W4220693419 title "Ultrasound-controllable engineered bacteria for cancer immunotherapy" @default.
• W4220693419 cites W1891302139 @default.
• W4220693419 cites W1914776013 @default.
• W4220693419 cites W1969545795 @default.
• W4220693419 cites W1970087240 @default.
• W4220693419 cites W1973123246 @default.
• W4220693419 cites W1978337610 @default.
• W4220693419 cites W1979197349 @default.
• W4220693419 cites W1984780645 @default.
• W4220693419 cites W2001426985 @default.
• W4220693419 cites W2019759182 @default.
• W4220693419 cites W2023429099 @default.
• W4220693419 cites W2024626049 @default.
• W4220693419 cites W2024678678 @default.
• W4220693419 cites W2026471860 @default.
• W4220693419 cites W2036650062 @default.
• W4220693419 cites W2044147171 @default.
• W4220693419 cites W2046894146 @default.
• W4220693419 cites W2048944905 @default.
• W4220693419 cites W2051132214 @default.
• W4220693419 cites W2052835050 @default.
• W4220693419 cites W2052869876 @default.
• W4220693419 cites W2084088713 @default.
• W4220693419 cites W2094244560 @default.
• W4220693419 cites W2099102896 @default.
• W4220693419 cites W2103722640 @default.
• W4220693419 cites W2110693589 @default.
• W4220693419 cites W2111756845 @default.
• W4220693419 cites W2115205513 @default.
• W4220693419 cites W2117986752 @default.
• W4220693419 cites W2119109373 @default.
• W4220693419 cites W2121572199 @default.
• W4220693419 cites W2129006693 @default.
• W4220693419 cites W2130696033 @default.
• W4220693419 cites W2131875133 @default.
• W4220693419 cites W2165885624 @default.
• W4220693419 cites W2167405280 @default.
• W4220693419 cites W2174688478 @default.
• W4220693419 cites W2181183219 @default.
• W4220693419 cites W2317656203 @default.
• W4220693419 cites W2346027246 @default.
• W4220693419 cites W2405531059 @default.
• W4220693419 cites W2468060912 @default.
• W4220693419 cites W2550813149 @default.
• W4220693419 cites W2586223583 @default.
• W4220693419 cites W2596760231 @default.
• W4220693419 cites W2598017149 @default.
• W4220693419 cites W2619290461 @default.
• W4220693419 cites W2621715610 @default.
• W4220693419 cites W2741116513 @default.
• W4220693419 cites W2755519984 @default.
• W4220693419 cites W2772970806 @default.
• W4220693419 cites W2779417696 @default.
• W4220693419 cites W2786946130 @default.
• W4220693419 cites W2794143268 @default.
• W4220693419 cites W2808638507 @default.
• W4220693419 cites W2898235576 @default.
• W4220693419 cites W2899862051 @default.
• W4220693419 cites W2945590213 @default.
• W4220693419 cites W2951096514 @default.
• W4220693419 cites W2955245896 @default.
• W4220693419 cites W2989837443 @default.
• W4220693419 cites W2991599782 @default.
• W4220693419 cites W2994932349 @default.
• W4220693419 cites W3005412445 @default.
• W4220693419 cites W3005566802 @default.
• W4220693419 cites W3015123349 @default.
• W4220693419 cites W3016253107 @default.
• W4220693419 cites W3030200736 @default.
• W4220693419 cites W3032567649 @default.
• W4220693419 cites W3046844939 @default.
• W4220693419 cites W3083110853 @default.
• W4220693419 cites W3111667196 @default.
• W4220693419 cites W3113346975 @default.
• W4220693419 cites W3120402208 @default.
• W4220693419 cites W3202833114 @default.
• W4220693419 cites W4211062740 @default.
• W4220693419 cites W4292250249 @default.
• W4220693419 doi "https://doi.org/10.1038/s41467-022-29065-2" @default.
• W4220693419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35332124" @default.
• W4220693419 hasPublicationYear "2022" @default.
• W4220693419 type Work @default.
• W4220693419 citedByCount "56" @default.
• W4220693419 countsByYear W42206934192021 @default.
• W4220693419 countsByYear W42206934192022 @default.
• W4220693419 countsByYear W42206934192023 @default.
• W4220693419 crossrefType "journal-article" @default.

• next