Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220694089> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W4220694089 abstract "Mammalian gonadal sex is determined by the presence or absence of a Y chromosome. In males, the Y chromosome initiates male gonadogenesis and the subsequent production of male-specific hormones defines the male state of each cell in the organism. In females, the lack of a Y chromosome and the presence of two X chromosomes triggers the development of female gonads, hormones, and cellular identity. However, sex chromosome-linked genes encoding dosage-sensitive transcription and epigenetic factors are expressed well before gonad formation and have the potential to establish sex-biased expression. Here we apply a comparative bioinformatic analysis on published single-cell datasets in mouse and human during very early embryogenesis - from two-cell to preimplantation stages - to characterize sex-specific signals and to assess the degree of conservation among early acting sex-specific genes and pathways. Clustering and regression analyses of gene expression across samples reveal that sex initially plays a significant role in overall gene expression patterns at the earliest stages of embryogenesis. In addition, gene expression signals from male and female gametes during fertilization may still be present. Although these transcriptional sex effects rapidly diminish, the sex-biased expression of epigenetic enzymes has the potential to establish sex-specific patterns that persist beyond implantation. Sex-biased genes appear to form sex-specific protein-protein interaction networks across preimplantation stages in both mammals. While the distribution of sex-differentially expressed genes (sexDEGs) in early embryonic stages are similar in mice and humans, the genes involved are generally different. Non-negative matrix factorization (NMF) on male and female transcriptomes generated clusters of genes with similar expression patterns across sex and developmental stages including post-fertilization, epigenetic, and preimplantation ontologies conserved between mouse and human. This comparative study uncovers much earlier than expected sex-specific signals in mouse and human embryos that pre-date hormonal signaling from the gonads. These early signals are diverged with respect to orthologs yet conserved in terms of function with important implications in the use of genetic models for sex-specific disease." @default.
- W4220694089 created "2022-04-03" @default.
- W4220694089 creator A5005162570 @default.
- W4220694089 creator A5035584099 @default.
- W4220694089 creator A5041214907 @default.
- W4220694089 creator A5044799458 @default.
- W4220694089 date "2022-03-19" @default.
- W4220694089 modified "2023-10-17" @default.
- W4220694089 title "Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals" @default.
- W4220694089 doi "https://doi.org/10.1101/2022.03.17.484606" @default.
- W4220694089 hasPublicationYear "2022" @default.
- W4220694089 type Work @default.
- W4220694089 citedByCount "0" @default.
- W4220694089 crossrefType "posted-content" @default.
- W4220694089 hasAuthorship W4220694089A5005162570 @default.
- W4220694089 hasAuthorship W4220694089A5035584099 @default.
- W4220694089 hasAuthorship W4220694089A5041214907 @default.
- W4220694089 hasAuthorship W4220694089A5044799458 @default.
- W4220694089 hasBestOaLocation W42206940891 @default.
- W4220694089 hasConcept C104317684 @default.
- W4220694089 hasConcept C150194340 @default.
- W4220694089 hasConcept C18431079 @default.
- W4220694089 hasConcept C2781037291 @default.
- W4220694089 hasConcept C35158069 @default.
- W4220694089 hasConcept C41091548 @default.
- W4220694089 hasConcept C4323932 @default.
- W4220694089 hasConcept C54355233 @default.
- W4220694089 hasConcept C86803240 @default.
- W4220694089 hasConcept C92509807 @default.
- W4220694089 hasConceptScore W4220694089C104317684 @default.
- W4220694089 hasConceptScore W4220694089C150194340 @default.
- W4220694089 hasConceptScore W4220694089C18431079 @default.
- W4220694089 hasConceptScore W4220694089C2781037291 @default.
- W4220694089 hasConceptScore W4220694089C35158069 @default.
- W4220694089 hasConceptScore W4220694089C41091548 @default.
- W4220694089 hasConceptScore W4220694089C4323932 @default.
- W4220694089 hasConceptScore W4220694089C54355233 @default.
- W4220694089 hasConceptScore W4220694089C86803240 @default.
- W4220694089 hasConceptScore W4220694089C92509807 @default.
- W4220694089 hasLocation W42206940891 @default.
- W4220694089 hasOpenAccess W4220694089 @default.
- W4220694089 hasPrimaryLocation W42206940891 @default.
- W4220694089 hasRelatedWork W14250495 @default.
- W4220694089 hasRelatedWork W17198291 @default.
- W4220694089 hasRelatedWork W22655121 @default.
- W4220694089 hasRelatedWork W23889238 @default.
- W4220694089 hasRelatedWork W25624748 @default.
- W4220694089 hasRelatedWork W27318365 @default.
- W4220694089 hasRelatedWork W29797865 @default.
- W4220694089 hasRelatedWork W32253327 @default.
- W4220694089 hasRelatedWork W39128466 @default.
- W4220694089 hasRelatedWork W4846663 @default.
- W4220694089 isParatext "false" @default.
- W4220694089 isRetracted "false" @default.
- W4220694089 workType "article" @default.