Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220694820> ?p ?o ?g. }
- W4220694820 endingPage "121488" @default.
- W4220694820 startingPage "121488" @default.
- W4220694820 abstract "Due to intrinsic and acquired chemo/radiotherapy-resistance, renal cell carcinoma shows limited therapeutic response to clinically utilized targeting drugs. Here a tumor-activated oncolytic peptide nanomachine is devised to selectively lysing tumor cell membrane without causing drug resistance. Specifically, in the acidic tumor microenvironment, the oncolytic peptide nanomachine automatically activated through morphologically transformation from nanoparticles to nanofibrils with restoring α-helical conformation, which physically bind to tumor cell membrane with multiple (spatially correlated and time-resolved) interactions and subsequently lyse local cell membrane. The IC50 of the oncolytic peptide nanomachine is as low as 2.44 μM and it inhibit up to 90% of tumor cells within 2 h with unique bystander killing effect. In vivo, the tumor inhibition rate of the oncolytic peptide nanomachine is 71% without off-target activity and hemolytic activity. These results support that tumor-selective oncolytic peptide nanomachine represent a promising alternative approach for multidrug-resistant tumor treatments by inducing cell membrane lysis." @default.
- W4220694820 created "2022-04-03" @default.
- W4220694820 creator A5012022826 @default.
- W4220694820 creator A5035871338 @default.
- W4220694820 creator A5038072419 @default.
- W4220694820 creator A5038335020 @default.
- W4220694820 creator A5041630113 @default.
- W4220694820 creator A5055879965 @default.
- W4220694820 creator A5057199801 @default.
- W4220694820 creator A5088509320 @default.
- W4220694820 date "2022-05-01" @default.
- W4220694820 modified "2023-10-17" @default.
- W4220694820 title "Oncolytic peptide nanomachine circumvents chemo resistance of renal cell carcinoma" @default.
- W4220694820 cites W128066484 @default.
- W4220694820 cites W1548453476 @default.
- W4220694820 cites W1937753295 @default.
- W4220694820 cites W1975929450 @default.
- W4220694820 cites W1985159801 @default.
- W4220694820 cites W1987436683 @default.
- W4220694820 cites W1987875997 @default.
- W4220694820 cites W1989821242 @default.
- W4220694820 cites W1990467750 @default.
- W4220694820 cites W2059807927 @default.
- W4220694820 cites W2060652930 @default.
- W4220694820 cites W2066623937 @default.
- W4220694820 cites W2068583619 @default.
- W4220694820 cites W2070632568 @default.
- W4220694820 cites W2078532650 @default.
- W4220694820 cites W2079217831 @default.
- W4220694820 cites W2093333472 @default.
- W4220694820 cites W2097633205 @default.
- W4220694820 cites W2107290421 @default.
- W4220694820 cites W2110380269 @default.
- W4220694820 cites W2149074724 @default.
- W4220694820 cites W2213504946 @default.
- W4220694820 cites W2531550383 @default.
- W4220694820 cites W2572758052 @default.
- W4220694820 cites W2748195373 @default.
- W4220694820 cites W2767025650 @default.
- W4220694820 cites W2810166643 @default.
- W4220694820 cites W2823865577 @default.
- W4220694820 cites W2886023217 @default.
- W4220694820 cites W2914277167 @default.
- W4220694820 cites W2967078590 @default.
- W4220694820 cites W2981352648 @default.
- W4220694820 cites W2982275548 @default.
- W4220694820 cites W2982402173 @default.
- W4220694820 cites W2990720920 @default.
- W4220694820 cites W3002244457 @default.
- W4220694820 cites W3010894414 @default.
- W4220694820 cites W3025175786 @default.
- W4220694820 cites W3044465089 @default.
- W4220694820 cites W3048612424 @default.
- W4220694820 cites W3087729783 @default.
- W4220694820 cites W3089461485 @default.
- W4220694820 cites W3098302367 @default.
- W4220694820 cites W3109462777 @default.
- W4220694820 cites W3111296631 @default.
- W4220694820 cites W3115667040 @default.
- W4220694820 cites W3119269938 @default.
- W4220694820 cites W3120676282 @default.
- W4220694820 cites W3136827720 @default.
- W4220694820 cites W3155774973 @default.
- W4220694820 cites W3199428814 @default.
- W4220694820 cites W4246169547 @default.
- W4220694820 doi "https://doi.org/10.1016/j.biomaterials.2022.121488" @default.
- W4220694820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35367840" @default.
- W4220694820 hasPublicationYear "2022" @default.
- W4220694820 type Work @default.
- W4220694820 citedByCount "4" @default.
- W4220694820 countsByYear W42206948202023 @default.
- W4220694820 crossrefType "journal-article" @default.
- W4220694820 hasAuthorship W4220694820A5012022826 @default.
- W4220694820 hasAuthorship W4220694820A5035871338 @default.
- W4220694820 hasAuthorship W4220694820A5038072419 @default.
- W4220694820 hasAuthorship W4220694820A5038335020 @default.
- W4220694820 hasAuthorship W4220694820A5041630113 @default.
- W4220694820 hasAuthorship W4220694820A5055879965 @default.
- W4220694820 hasAuthorship W4220694820A5057199801 @default.
- W4220694820 hasAuthorship W4220694820A5088509320 @default.
- W4220694820 hasConcept C114851261 @default.
- W4220694820 hasConcept C133936738 @default.
- W4220694820 hasConcept C1491633281 @default.
- W4220694820 hasConcept C150903083 @default.
- W4220694820 hasConcept C185592680 @default.
- W4220694820 hasConcept C192562407 @default.
- W4220694820 hasConcept C207001950 @default.
- W4220694820 hasConcept C2778106830 @default.
- W4220694820 hasConcept C2779281246 @default.
- W4220694820 hasConcept C3020616263 @default.
- W4220694820 hasConcept C502942594 @default.
- W4220694820 hasConcept C55493867 @default.
- W4220694820 hasConcept C57409179 @default.
- W4220694820 hasConcept C82210918 @default.
- W4220694820 hasConcept C86803240 @default.
- W4220694820 hasConcept C89423630 @default.
- W4220694820 hasConceptScore W4220694820C114851261 @default.
- W4220694820 hasConceptScore W4220694820C133936738 @default.