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- W4220696069 abstract "Drug resistance against antimalarials is inevitable, usually emerging slowly for approximately 20 years after they start being widely used, at which point there is a sudden onset of widespread resistance. 1 Feachem RGA Chen I Akbari O et al. Malaria eradication within a generation: ambitious, achievable, and necessary. Lancet. 2019; 394: 1056-1112 Summary Full Text Full Text PDF PubMed Scopus (147) Google Scholar This pattern has been seen for chloroquine, sulfadoxine-pyrimethamine, and most recently the components of artemisinin-based combination therapy (ACT), emphasising the need for a robust antimalarial drug pipeline featuring compounds with novel modes of action until global malaria eradication is achieved. While we await new compounds—seven of which are in translational and human exploratory studies but might fail at later stages of the pipeline 2 Medicines for Malaria VentureProjects MfMVS. https://www.mmv.org/research-development/mmv-supported-projectsDate accessed: November 8, 2021 Google Scholar —additional strategies are urgently needed to curb the persistent and rapid emergence of resistance to artemisinin-class and partner drugs. Triple therapy with artemether–lumefantrine plus amodiaquine versus artemether–lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trialArtemether–lumefantrine plus amodiaquine provides an alternative to artemether–lumefantrine alone as first-line treatment for multidrug-resistant P falciparum malaria in the Greater Mekong subregion, and could prolong the therapeutic lifetime of artemether–lumefantrine in malaria-endemic populations. Full-Text PDF Open Access" @default.
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- W4220696069 date "2022-06-01" @default.
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- W4220696069 title "Triple artemisinin-based combination therapies for malaria: a timely solution to counter antimalarial drug resistance" @default.
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- W4220696069 doi "https://doi.org/10.1016/s1473-3099(21)00748-9" @default.
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