Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220699574> ?p ?o ?g. }
- W4220699574 abstract "The phosphatidylinositol 3-kinase (PI3K) pathway is an intracellular pathway activated in response to progrowth signaling, such as human epidermal growth factor receptor 2 (HER2) and other kinases. Abnormal activation of PI3K has long been recognized as one of the main oncogenic drivers in breast cancer, including HER2-positive (HER2+) subtype. Somatic activating mutations in the gene encoding PI3K alpha catalytic subunit (PIK3CA) are present in approximately 30% of early-stage HER2+ tumors and drive therapeutic resistance to multiple HER2-targeted agents. Here, we review currently available agents targeting PI3K, discuss their potential role in HER2+ breast cancer, and provide an overview of ongoing trials of PI3K inhibitors in HER2+ disease. Additionally, we review the landscape of PIK3CA mutational testing and highlight the gaps in knowledge that could present potential barriers in the effective application of PI3K inhibitors for treatment of HER2+ breast cancer." @default.
- W4220699574 created "2022-04-03" @default.
- W4220699574 creator A5001552474 @default.
- W4220699574 creator A5001562050 @default.
- W4220699574 creator A5016728798 @default.
- W4220699574 creator A5021938970 @default.
- W4220699574 creator A5052885079 @default.
- W4220699574 creator A5085978470 @default.
- W4220699574 date "2022-05-01" @default.
- W4220699574 modified "2023-10-16" @default.
- W4220699574 title "<i>PIK3CA</i>Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer" @default.
- W4220699574 cites W1887489362 @default.
- W4220699574 cites W1920844816 @default.
- W4220699574 cites W1971525986 @default.
- W4220699574 cites W1975570973 @default.
- W4220699574 cites W1977701732 @default.
- W4220699574 cites W1978194521 @default.
- W4220699574 cites W1987759199 @default.
- W4220699574 cites W1992477322 @default.
- W4220699574 cites W2009886463 @default.
- W4220699574 cites W2020372547 @default.
- W4220699574 cites W2023041438 @default.
- W4220699574 cites W2025935112 @default.
- W4220699574 cites W2029166421 @default.
- W4220699574 cites W2029286823 @default.
- W4220699574 cites W2029682365 @default.
- W4220699574 cites W2037578452 @default.
- W4220699574 cites W2039071845 @default.
- W4220699574 cites W2044702943 @default.
- W4220699574 cites W2056427943 @default.
- W4220699574 cites W2096283457 @default.
- W4220699574 cites W2101982508 @default.
- W4220699574 cites W2103808574 @default.
- W4220699574 cites W2104659222 @default.
- W4220699574 cites W2106947763 @default.
- W4220699574 cites W2114621233 @default.
- W4220699574 cites W2114843025 @default.
- W4220699574 cites W2118419063 @default.
- W4220699574 cites W2123591186 @default.
- W4220699574 cites W2138264320 @default.
- W4220699574 cites W2139345040 @default.
- W4220699574 cites W2139712038 @default.
- W4220699574 cites W2149441684 @default.
- W4220699574 cites W2151258296 @default.
- W4220699574 cites W2153096480 @default.
- W4220699574 cites W2156918228 @default.
- W4220699574 cites W2159990074 @default.
- W4220699574 cites W2162901058 @default.
- W4220699574 cites W2163898107 @default.
- W4220699574 cites W2167188058 @default.
- W4220699574 cites W2168133196 @default.
- W4220699574 cites W2264980831 @default.
- W4220699574 cites W2286693725 @default.
- W4220699574 cites W2294679176 @default.
- W4220699574 cites W2334089645 @default.
- W4220699574 cites W2339101518 @default.
- W4220699574 cites W2342880723 @default.
- W4220699574 cites W2343358448 @default.
- W4220699574 cites W2346465624 @default.
- W4220699574 cites W2352525452 @default.
- W4220699574 cites W2379981061 @default.
- W4220699574 cites W2412777305 @default.
- W4220699574 cites W2475548831 @default.
- W4220699574 cites W2494188136 @default.
- W4220699574 cites W2497521261 @default.
- W4220699574 cites W2509236360 @default.
- W4220699574 cites W2525724642 @default.
- W4220699574 cites W2546933714 @default.
- W4220699574 cites W2560367415 @default.
- W4220699574 cites W2563045493 @default.
- W4220699574 cites W2581395526 @default.
- W4220699574 cites W2585697071 @default.
- W4220699574 cites W2587365770 @default.
- W4220699574 cites W2594062880 @default.
- W4220699574 cites W2614443510 @default.
- W4220699574 cites W2619858681 @default.
- W4220699574 cites W2624559025 @default.
- W4220699574 cites W2754374743 @default.
- W4220699574 cites W2758131690 @default.
- W4220699574 cites W2762226752 @default.
- W4220699574 cites W2765242536 @default.
- W4220699574 cites W2775764871 @default.
- W4220699574 cites W2780640138 @default.
- W4220699574 cites W2786945112 @default.
- W4220699574 cites W2789281724 @default.
- W4220699574 cites W2790516087 @default.
- W4220699574 cites W2800589452 @default.
- W4220699574 cites W2806209829 @default.
- W4220699574 cites W2807211107 @default.
- W4220699574 cites W2891700678 @default.
- W4220699574 cites W2897570808 @default.
- W4220699574 cites W2898683836 @default.
- W4220699574 cites W2904293303 @default.
- W4220699574 cites W2921991537 @default.
- W4220699574 cites W2923800831 @default.
- W4220699574 cites W2945177002 @default.
- W4220699574 cites W2945564879 @default.
- W4220699574 cites W2947111998 @default.
- W4220699574 cites W2971650649 @default.
- W4220699574 cites W2982786587 @default.