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- W4220703934 endingPage "21.2021" @default.
- W4220703934 startingPage "ENEURO.0510" @default.
- W4220703934 abstract "Autonomic parasympathetic preganglionic neurons (PGNs) drive contraction of the bladder during micturition but remain quiescent during bladder filling. This quiescence is postulated to be because of recurrent inhibition of PGN by fast-firing adjoining interneurons. Here, we defined four distinct neuronal types within Lamina VII, where PGN are situated, by combining whole cell patch clamp recordings with k-means clustering of a range of electrophysiological parameters. Additional morphologic analysis separated these neuronal classes into parasympathetic preganglionic populations (PGN) and a fast-firing interneuronal population. Kv3 channels are voltage-gated potassium channels (Kv) that allow fast and precise firing of neurons. We found that blockade of Kv3 channels by tetraethylammonium (TEA) reduced neuronal firing frequency and isolated high-voltage-activated Kv currents in the fast-firing population but had no effect in PGN populations. Furthermore, Kv3 blockade potentiated the local and descending inhibitory inputs to PGN indicating that Kv3-expressing inhibitory neurons are synaptically connected to PGN. Taken together, our data reveal that Kv3 channels are crucial for fast and regulated neuronal output of a defined population that may be involved in intrinsic spinal bladder circuits that underpin recurrent inhibition of PGN." @default.
- W4220703934 created "2022-04-03" @default.
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- W4220703934 date "2022-01-01" @default.
- W4220703934 modified "2023-10-04" @default.
- W4220703934 title "Kv3 Channels Contribute to the Excitability of Subpopulations of Spinal Cord Neurons in Lamina VII" @default.
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- W4220703934 doi "https://doi.org/10.1523/eneuro.0510-21.2021" @default.
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