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• W4220706057 abstract "Arsenic trioxide (ATO) has been a highly promising chemotherapeutic drug for treating APL patients in the last decades. Owing to its complications, researchers are enthusiastic about applying compounds with fewer side effects, especially in a combined modality. Therefore, due to the anti-cancer properties of VitD3, our investigation was aimed to highlight the Vit-D3/ATO combination effects on the NB4 leukemic cells. The APL cell line (NB4) was cultured with various VitD3, ATO, and Vit-D3/ATO concentrations. Afterward, the cell viability was evaluated via MTT and trypan blue assays. In addition, the apoptosis and Gene expression were assessed using Flow cytometry and qRT-PCR, respectively. Our findings revealed that Vit-D3 applied apoptotic and growth inhibitory effects in a dose and time-dependent manner. Moreover, Vit-D3/ATO combination augmented the effects of ATO on regulated cell death via a remarkable elevation in the BAX/BCL-2 ratio in comparison with single treatments. Given the synergistic effects of the Vit-D3/ATO combination, our study suggests a promising therapeutic strategy for APL treatment." @default.
• W4220706057 created "2022-04-03" @default.
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• W4220706057 date "2022-06-01" @default.
• W4220706057 modified "2023-10-18" @default.
• W4220706057 title "Vitamin D3, arsenic trioxide, or combination therapy for acute promyelocytic leukemia" @default.
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• W4220706057 doi "https://doi.org/10.1016/j.genrep.2022.101576" @default.
• W4220706057 hasPublicationYear "2022" @default.
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