FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220711780> ?p ?o ?g. }

• W4220711780 endingPage "12" @default.
• W4220711780 startingPage "1" @default.
• W4220711780 abstract "Bleomycin is a common antitumor agent used to treat many different types of malignancies; however, its main side effect is pulmonary fibrosis. The mechanism of bleomycin-induced pulmonary fibrosis (BIPF) has not been fully elucidated. Therefore, to further explore the molecular mechanisms of BIPF, we screened for microRNA (miRNA) and mRNA expression obtained from BIPF samples from the Gene Expression Omnibus database. Subsequently, we identified the differentially expressed miRNAs and genes that overlapped with the differentially expressed miRNAs target genes, predicted by using the miRWalk database selected as a candidate. The candidate genes were visualized based on Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes analyses. A protein-protein interaction network was constructed. Hub differentially expressed genes were selected and corresponding miRNAs to construct a miRNA-mRNA regulation network. Then, we chose three key miRNAs to study their regulatory relationship in bleomycin-induced pulmonary fibrosis. Finally, mouse lung epithelial cells TC-1 and MLE-12 were treated with bleomycin with qPCR to validate the results of three important hub genes and all key miRNAs. And dual-luciferase report experiment was carried out to verify the interaction of mmu-miR-1946a and serpina3n. The results revealed that the imbalance of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) plays a pivotal role in the occurrence and development of BIPF. In addition, Serpina3n and mmu-miR-1946a were proved interaction and may be involved in the regulation of the balance between MMP-9 and TIMP-1. The experimental results also verify the analysis. Our findings provide new insights into the key mediators and pathways related to the molecular mechanisms of BIPF." @default.
• W4220711780 created "2022-04-03" @default.
• W4220711780 creator A5006083516 @default.
• W4220711780 creator A5018783931 @default.
• W4220711780 creator A5019047597 @default.
• W4220711780 creator A5021287431 @default.
• W4220711780 creator A5024056860 @default.
• W4220711780 creator A5053878641 @default.
• W4220711780 creator A5054044981 @default.
• W4220711780 creator A5056790869 @default.
• W4220711780 creator A5080344483 @default.
• W4220711780 creator A5081163770 @default.
• W4220711780 date "2022-03-30" @default.
• W4220711780 modified "2023-10-15" @default.
• W4220711780 title "Construction of MicroRNA-mRNA Regulatory Network in the Molecular Mechanisms of Bleomycin-Induced Pulmonary Fibrosis" @default.
• W4220711780 cites W148052990 @default.
• W4220711780 cites W1676246072 @default.
• W4220711780 cites W1993687314 @default.
• W4220711780 cites W2020541351 @default.
• W4220711780 cites W2057793596 @default.
• W4220711780 cites W2081406906 @default.
• W4220711780 cites W2094835614 @default.
• W4220711780 cites W2099297962 @default.
• W4220711780 cites W2102395431 @default.
• W4220711780 cites W2103912979 @default.
• W4220711780 cites W2116634113 @default.
• W4220711780 cites W2118258530 @default.
• W4220711780 cites W2122683221 @default.
• W4220711780 cites W2135449612 @default.
• W4220711780 cites W2154401382 @default.
• W4220711780 cites W2163106706 @default.
• W4220711780 cites W2170327826 @default.
• W4220711780 cites W2341128841 @default.
• W4220711780 cites W2537623931 @default.
• W4220711780 cites W2560493566 @default.
• W4220711780 cites W2593459113 @default.
• W4220711780 cites W2607129810 @default.
• W4220711780 cites W2786728433 @default.
• W4220711780 cites W2793317283 @default.
• W4220711780 cites W2897825874 @default.
• W4220711780 cites W2912369247 @default.
• W4220711780 cites W2922501621 @default.
• W4220711780 cites W296319558 @default.
• W4220711780 cites W2972871103 @default.
• W4220711780 cites W2981487055 @default.
• W4220711780 cites W2997137076 @default.
• W4220711780 cites W3011623493 @default.
• W4220711780 cites W3029836108 @default.
• W4220711780 cites W3097703774 @default.
• W4220711780 cites W4247544731 @default.
• W4220711780 doi "https://doi.org/10.1155/2022/7367328" @default.
• W4220711780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35402615" @default.
• W4220711780 hasPublicationYear "2022" @default.
• W4220711780 type Work @default.
• W4220711780 citedByCount "0" @default.
• W4220711780 crossrefType "journal-article" @default.
• W4220711780 hasAuthorship W4220711780A5006083516 @default.
• W4220711780 hasAuthorship W4220711780A5018783931 @default.
• W4220711780 hasAuthorship W4220711780A5019047597 @default.
• W4220711780 hasAuthorship W4220711780A5021287431 @default.
• W4220711780 hasAuthorship W4220711780A5024056860 @default.
• W4220711780 hasAuthorship W4220711780A5053878641 @default.
• W4220711780 hasAuthorship W4220711780A5054044981 @default.
• W4220711780 hasAuthorship W4220711780A5056790869 @default.
• W4220711780 hasAuthorship W4220711780A5080344483 @default.
• W4220711780 hasAuthorship W4220711780A5081163770 @default.
• W4220711780 hasBestOaLocation W42207117801 @default.
• W4220711780 hasConcept C104317684 @default.
• W4220711780 hasConcept C105580179 @default.
• W4220711780 hasConcept C142724271 @default.
• W4220711780 hasConcept C145059251 @default.
• W4220711780 hasConcept C150194340 @default.
• W4220711780 hasConcept C152724338 @default.
• W4220711780 hasConcept C162317418 @default.
• W4220711780 hasConcept C2776232574 @default.
• W4220711780 hasConcept C2776694085 @default.
• W4220711780 hasConcept C2780559512 @default.
• W4220711780 hasConcept C2781244666 @default.
• W4220711780 hasConcept C502942594 @default.
• W4220711780 hasConcept C54355233 @default.
• W4220711780 hasConcept C60644358 @default.
• W4220711780 hasConcept C67339327 @default.
• W4220711780 hasConcept C70721500 @default.
• W4220711780 hasConcept C71924100 @default.
• W4220711780 hasConcept C86803240 @default.
• W4220711780 hasConceptScore W4220711780C104317684 @default.
• W4220711780 hasConceptScore W4220711780C105580179 @default.
• W4220711780 hasConceptScore W4220711780C142724271 @default.
• W4220711780 hasConceptScore W4220711780C145059251 @default.
• W4220711780 hasConceptScore W4220711780C150194340 @default.
• W4220711780 hasConceptScore W4220711780C152724338 @default.
• W4220711780 hasConceptScore W4220711780C162317418 @default.
• W4220711780 hasConceptScore W4220711780C2776232574 @default.
• W4220711780 hasConceptScore W4220711780C2776694085 @default.
• W4220711780 hasConceptScore W4220711780C2780559512 @default.
• W4220711780 hasConceptScore W4220711780C2781244666 @default.
• W4220711780 hasConceptScore W4220711780C502942594 @default.
• W4220711780 hasConceptScore W4220711780C54355233 @default.

• next