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- W4220715158 startingPage "273" @default.
- W4220715158 abstract "After nearly 50 years of research and development, peptide therapeutics have dramatically evolved from rather simple chemical structures (oftentimes linear and relatively short sequences) to both diverse and complex peptide modalities (including macrocyclic and relatively long sequences). Beyond chemistry, the design and delivery of peptide therapeutics has advanced incredibly by virtue of structural biology (e.g. X-ray, NMR, and other biophysical methods), computational chemistry, cheminformatics, and drug delivery (e.g. intravenous, subcutaneous, nasal, and oral routes of administration). Indeed, these are the days of the peptide drug hunter and the rise of a molecular armamentarium of peptide therapeutics being developed against a wide spectrum of disease targets (e.g. receptor and extracellular targets, proteases, and an increasing number of intracellular targets, including enzymes, protein–protein interactions, and both transcription and translation factors). Nowadays, the peptide drug hunter is able to leverage multidisciplinary knowledge, technologies and momentum via a highly networked academic, pharmaceutical and biotechnology enterprise. This chapter is intended to provide a perspective of macrocyclic peptide modalities that are being advanced against numerous disease targets and highlight innovative advancements in both peptide design and peptide delivery strategies." @default.
- W4220715158 created "2022-04-03" @default.
- W4220715158 creator A5082655309 @default.
- W4220715158 date "2022-03-07" @default.
- W4220715158 modified "2023-09-27" @default.
- W4220715158 title "Entrepreneurial Drug Hunter" @default.
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