FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220715726> ?p ?o ?g. }

• W4220715726 abstract "Abstract Endometrial hyperplasia (EH) is a precursor lesion to endometrial carcinoma (EC). Risks for EC include genetic, hormonal and metabolic factors most notably those associated with obesity: rates are rising and there is concern that cases in pre-menopausal women may remain undetected. Making an accurate distinction between benign and pre-malignant disease is both a challenge for the pathologist and important to the gynaecologist who wants to deliver the most appropriate care to meet the needs of the patient. Premalignant change may be recognised by histological changes of endometrial hyperplasia (which may occur with or without atypia) and endometrial intraepithelial neoplasia (EIN). In this study we created a tissue resource of EH samples diagnosed between 2004 and 2009 (n=125) and used this to address key questions: 1. Are the EIN/WHO2014 diagnostic criteria able to consistently identify premalignant endometrium? 2. Can computer aided image analysis inform identification of EIN? 3. Can we improve diagnosis by incorporating analysis of protein expression using immunohistochemistry. Our findings confirmed the inclusion of EIN in diagnostic criteria resulted in a better agreement between expert pathologists compared with the previous WHO94 criteria used for the original diagnosis of our sample set. A computer model based on assessment of stromal:epithelial ratio appeared most accurate in classification of areas of tissue without EIN. From an extensive panel of putative endometrial protein tissue biomarkers a score based on assessment of HAND2, PTEN and PAX2 was able to identify four clusters one of which appeared to be more likely to be benign. In summary, our study has highlighted new opportunities to improve diagnosis of pre-malignant disease in endometrium and provide a platform for further research on this important topic. Highlights Blinded re-analysis of n=125 samples previously classified as endometrial hyperplasia found improved intra-observer agreement (67%) using EIN/WHO2014 compared with standard WHO1994 criteria (52%) Computerised analysis of endometrial hyperplasia tissue architecture showed promise as a tool to assist pathologists in diagnosis of difficult to classify cases A diagnosis of endometrial intraepithelial neoplasia (EIN) using the WHO2014 criteria more accurately predicted risk of endometrial cancer than WHO1994 system. EIN samples exhibited altered expression of ARID1A (negative glands) and HAND2 (reduced or absent from stroma) Unsupervised hierarchical cluster analysis based on immunostaining for PTEN, PAX2 and HAND2 identified 4 subtypes one of which segregated with benign disease. These results provide a framework for improved classification of pre-malignant lesions in endometrium that may inform personalized care pathways" @default.
• W4220715726 created "2022-04-03" @default.
• W4220715726 creator A5019378167 @default.
• W4220715726 creator A5019395613 @default.
• W4220715726 creator A5030863406 @default.
• W4220715726 creator A5057993063 @default.
• W4220715726 creator A5066889367 @default.
• W4220715726 creator A5088347483 @default.
• W4220715726 creator A5090464916 @default.
• W4220715726 date "2022-03-08" @default.
• W4220715726 modified "2023-10-01" @default.
• W4220715726 title "Improving the diagnosis of endometrial hyperplasia using computerized analysis and immunohistochemical biomarkers" @default.
• W4220715726 cites W1507577134 @default.
• W4220715726 cites W1966125184 @default.
• W4220715726 cites W1992665115 @default.
• W4220715726 cites W1993198803 @default.
• W4220715726 cites W1994439119 @default.
• W4220715726 cites W1996130791 @default.
• W4220715726 cites W2005747556 @default.
• W4220715726 cites W2009350168 @default.
• W4220715726 cites W2009730315 @default.
• W4220715726 cites W2011974052 @default.
• W4220715726 cites W2030356933 @default.
• W4220715726 cites W2030781910 @default.
• W4220715726 cites W2034978601 @default.
• W4220715726 cites W2036553081 @default.
• W4220715726 cites W2041440766 @default.
• W4220715726 cites W2046487763 @default.
• W4220715726 cites W2052848503 @default.
• W4220715726 cites W2063680792 @default.
• W4220715726 cites W2064413548 @default.
• W4220715726 cites W2065406098 @default.
• W4220715726 cites W2097113048 @default.
• W4220715726 cites W2099952417 @default.
• W4220715726 cites W2113190292 @default.
• W4220715726 cites W2148651857 @default.
• W4220715726 cites W2150926065 @default.
• W4220715726 cites W2151052080 @default.
• W4220715726 cites W2157371671 @default.
• W4220715726 cites W2321263150 @default.
• W4220715726 cites W2417320495 @default.
• W4220715726 cites W2518381736 @default.
• W4220715726 cites W2537396286 @default.
• W4220715726 cites W2560061424 @default.
• W4220715726 cites W2737584524 @default.
• W4220715726 cites W2894777162 @default.
• W4220715726 cites W2896489165 @default.
• W4220715726 cites W2918325981 @default.
• W4220715726 cites W2946378604 @default.
• W4220715726 cites W2981009510 @default.
• W4220715726 cites W3002978984 @default.
• W4220715726 cites W3041311787 @default.
• W4220715726 cites W3046135873 @default.
• W4220715726 cites W3100887207 @default.
• W4220715726 cites W3105190579 @default.
• W4220715726 cites W3141621254 @default.
• W4220715726 cites W3183231717 @default.
• W4220715726 cites W3201743305 @default.
• W4220715726 cites W3202789706 @default.
• W4220715726 cites W3206570455 @default.
• W4220715726 cites W3208869610 @default.
• W4220715726 cites W3210761567 @default.
• W4220715726 cites W3213308437 @default.
• W4220715726 cites W3213382038 @default.
• W4220715726 doi "https://doi.org/10.1101/2022.02.27.22271450" @default.
• W4220715726 hasPublicationYear "2022" @default.
• W4220715726 type Work @default.
• W4220715726 citedByCount "0" @default.
• W4220715726 crossrefType "posted-content" @default.
• W4220715726 hasAuthorship W4220715726A5019378167 @default.
• W4220715726 hasAuthorship W4220715726A5019395613 @default.
• W4220715726 hasAuthorship W4220715726A5030863406 @default.
• W4220715726 hasAuthorship W4220715726A5057993063 @default.
• W4220715726 hasAuthorship W4220715726A5066889367 @default.
• W4220715726 hasAuthorship W4220715726A5088347483 @default.
• W4220715726 hasAuthorship W4220715726A5090464916 @default.
• W4220715726 hasBestOaLocation W42207157261 @default.
• W4220715726 hasConcept C121608353 @default.
• W4220715726 hasConcept C126322002 @default.
• W4220715726 hasConcept C142724271 @default.
• W4220715726 hasConcept C143998085 @default.
• W4220715726 hasConcept C190283241 @default.
• W4220715726 hasConcept C204232928 @default.
• W4220715726 hasConcept C2775934546 @default.
• W4220715726 hasConcept C2777088508 @default.
• W4220715726 hasConcept C2777546739 @default.
• W4220715726 hasConcept C2777562237 @default.
• W4220715726 hasConcept C2777609662 @default.
• W4220715726 hasConcept C2777689261 @default.
• W4220715726 hasConcept C2779742232 @default.
• W4220715726 hasConcept C2781283455 @default.
• W4220715726 hasConcept C29456083 @default.
• W4220715726 hasConcept C55493867 @default.
• W4220715726 hasConcept C71924100 @default.
• W4220715726 hasConcept C86554907 @default.
• W4220715726 hasConcept C86803240 @default.
• W4220715726 hasConceptScore W4220715726C121608353 @default.
• W4220715726 hasConceptScore W4220715726C126322002 @default.
• W4220715726 hasConceptScore W4220715726C142724271 @default.
• W4220715726 hasConceptScore W4220715726C143998085 @default.

• next