Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220727504> ?p ?o ?g. }
- W4220727504 endingPage "10932" @default.
- W4220727504 startingPage "10921" @default.
- W4220727504 abstract "Several studies have reported that dietary fibers (DFs) from plants may exert beneficial effects on inflammatory bowel disease. In the present study, we investigated the structural differences of soluble DF (inulin) and insoluble DF (microcrystalline cellulose, MCC) and their effects on the intestinal barrier integrity, gut microbiota community, and inflammation response in mice with dextran sodium sulfate (DSS)-induced colitis. Mice were fed for 21 days with diets containing inulin or MCC (2.5 g/kg body weight), and colitis was induced by administration of DSS (4% w/v) in drinking water during the last 8 days of experimentation. The results showed that inulin and MCC differ in morphology and structure. MCC exhibited a smaller particle size, a larger specific surface area, and higher thermal stability than inulin. In addition, both inulin and MCC restored various physical signs (body weight, colon weight and length, disease activity index score, and infiltration of inflammatory cells), gut barrier function (as evidenced by the increased expression of claudin-3, claudin-7, ZO-2, occludin, JAM-2, and MUC-3 and the decreased activity of myeloperoxidase activity), downregulation of mRNA expression of proinflammatory cytokines (caspase-1, NLPR3, TLR4, TNF-α, and IL-1β), and modulation of colon microbiota community. Taken together, the present study demonstrates that DFs differ in morphology and structure and ameliorate DSS-induced colitis in mice by blocking proinflammatory cytokines, reinforcing gut barrier integrity, and modulating gut microbiota. Therefore, DFs, especially inulin, are promising dietary supplements to alleviate intestinal inflammation." @default.
- W4220727504 created "2022-04-03" @default.
- W4220727504 creator A5012071300 @default.
- W4220727504 creator A5013186280 @default.
- W4220727504 creator A5015199708 @default.
- W4220727504 creator A5017945055 @default.
- W4220727504 creator A5020958040 @default.
- W4220727504 creator A5034114725 @default.
- W4220727504 creator A5041037235 @default.
- W4220727504 creator A5057970491 @default.
- W4220727504 creator A5075415907 @default.
- W4220727504 creator A5080052073 @default.
- W4220727504 creator A5088648468 @default.
- W4220727504 date "2022-03-23" @default.
- W4220727504 modified "2023-10-17" @default.
- W4220727504 title "Structural Characteristics of Inulin and Microcrystalline Cellulose and Their Effect on Ameliorating Colitis and Altering Colonic Microbiota in Dextran Sodium Sulfate-Induced Colitic Mice" @default.
- W4220727504 cites W1423072695 @default.
- W4220727504 cites W1824897516 @default.
- W4220727504 cites W1894493915 @default.
- W4220727504 cites W1950814327 @default.
- W4220727504 cites W1964575200 @default.
- W4220727504 cites W1968757995 @default.
- W4220727504 cites W1972427749 @default.
- W4220727504 cites W1976470241 @default.
- W4220727504 cites W1995923174 @default.
- W4220727504 cites W2012234834 @default.
- W4220727504 cites W2034104467 @default.
- W4220727504 cites W2062849663 @default.
- W4220727504 cites W2064188523 @default.
- W4220727504 cites W2067187611 @default.
- W4220727504 cites W2085575263 @default.
- W4220727504 cites W2093351631 @default.
- W4220727504 cites W2117301113 @default.
- W4220727504 cites W2124111075 @default.
- W4220727504 cites W2139890082 @default.
- W4220727504 cites W2233586474 @default.
- W4220727504 cites W2512894655 @default.
- W4220727504 cites W2562326846 @default.
- W4220727504 cites W2567911426 @default.
- W4220727504 cites W2587812371 @default.
- W4220727504 cites W2596770143 @default.
- W4220727504 cites W2597445613 @default.
- W4220727504 cites W2601441442 @default.
- W4220727504 cites W2609398719 @default.
- W4220727504 cites W2621499822 @default.
- W4220727504 cites W2734463380 @default.
- W4220727504 cites W2755250906 @default.
- W4220727504 cites W2768235035 @default.
- W4220727504 cites W2768507206 @default.
- W4220727504 cites W2776874704 @default.
- W4220727504 cites W2781993665 @default.
- W4220727504 cites W2782959446 @default.
- W4220727504 cites W2785059640 @default.
- W4220727504 cites W2793193730 @default.
- W4220727504 cites W2796603160 @default.
- W4220727504 cites W2802421303 @default.
- W4220727504 cites W2810902558 @default.
- W4220727504 cites W2884174586 @default.
- W4220727504 cites W2914900982 @default.
- W4220727504 cites W2915778198 @default.
- W4220727504 cites W2920541859 @default.
- W4220727504 cites W2920984735 @default.
- W4220727504 cites W2926665295 @default.
- W4220727504 cites W2939628846 @default.
- W4220727504 cites W2944911353 @default.
- W4220727504 cites W2950915423 @default.
- W4220727504 cites W2953905607 @default.
- W4220727504 cites W2972666844 @default.
- W4220727504 cites W2973453278 @default.
- W4220727504 cites W2986645936 @default.
- W4220727504 cites W2996078610 @default.
- W4220727504 cites W2999847951 @default.
- W4220727504 cites W3003160565 @default.
- W4220727504 cites W3005640882 @default.
- W4220727504 cites W3006197581 @default.
- W4220727504 cites W3042614626 @default.
- W4220727504 cites W3043160041 @default.
- W4220727504 cites W3044478834 @default.
- W4220727504 cites W3118605616 @default.
- W4220727504 cites W3157156346 @default.
- W4220727504 cites W3187968804 @default.
- W4220727504 doi "https://doi.org/10.1021/acsomega.1c06552" @default.
- W4220727504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35415348" @default.
- W4220727504 hasPublicationYear "2022" @default.
- W4220727504 type Work @default.
- W4220727504 citedByCount "5" @default.
- W4220727504 countsByYear W42207275042022 @default.
- W4220727504 countsByYear W42207275042023 @default.
- W4220727504 crossrefType "journal-article" @default.
- W4220727504 hasAuthorship W4220727504A5012071300 @default.
- W4220727504 hasAuthorship W4220727504A5013186280 @default.
- W4220727504 hasAuthorship W4220727504A5015199708 @default.
- W4220727504 hasAuthorship W4220727504A5017945055 @default.
- W4220727504 hasAuthorship W4220727504A5020958040 @default.
- W4220727504 hasAuthorship W4220727504A5034114725 @default.
- W4220727504 hasAuthorship W4220727504A5041037235 @default.
- W4220727504 hasAuthorship W4220727504A5057970491 @default.
- W4220727504 hasAuthorship W4220727504A5075415907 @default.