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• W4220729213 endingPage "103978" @default.
• W4220729213 startingPage "103978" @default.
• W4220729213 abstract "Severe COVID-19 T-cell lymphopenia is more common among older adults and entails poor prognosis. Offsetting the decline in T-cell count during COVID-19 demands fast and massive T-cell clonal expansion, which is telomere length (TL)-dependent.We developed a model of TL-dependent T-cell clonal expansion capacity with age and virtually examined the relation of T-cell clonal expansion with COVID-19 mortality in the general population.The model shows that an individual with average hematopoietic cell TL (HCTL) at age twenty years maintains maximal T-cell clonal expansion capacity until the 6th decade of life when this capacity rapidly declines by more than 90% over the next ten years. The collapse in the T-cell clonal expansion capacity coincides with the steep increase in COVID-19 mortality with age.Short HCTL might increase vulnerability of many older adults, and some younger individuals with inherently short HCTL, to COVID-19 T-cell lymphopenia and severe disease.A full list of funding bodies that contributed to this study can be found in the Acknowledgements section." @default.
• W4220729213 created "2022-04-03" @default.
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• W4220729213 date "2022-04-01" @default.
• W4220729213 modified "2023-10-17" @default.
• W4220729213 title "Telomere-length dependent T-cell clonal expansion: A model linking ageing to COVID-19 T-cell lymphopenia and mortality" @default.
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• W4220729213 doi "https://doi.org/10.1016/j.ebiom.2022.103978" @default.
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