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- W4220731647 endingPage "386" @default.
- W4220731647 startingPage "371" @default.
- W4220731647 abstract "Abstract The ability of a ketogenic diet to treat seizures and to render a neuronal network more resistant to strong electrical activity has been observed for a century in clinics and for decades in research laboratories. Along with ongoing efforts to understand how this therapy works to stop seizures, metabolic health is increasingly appreciated as a critical buffer to resisting and recovering from acute and chronic disease. Accordingly, links between metabolism and health, and the broader emerging impact of the ketogenic diet in improving diverse metabolic, immunologic, and neurologic conditions, have served to intensify the search for its key and/or common mechanisms. Here, diverse evidence for increased levels of NAD+, and thus an altered NAD+/NADH ratio, during ketogenic therapy is reviewed. Increased NAD+ is a potential unifying mechanism, and the chapter highlights some of the evidence linking an altered NAD+/NADH ratio with reduced seizures and with a range of short and long-term changes associated with the beneficial effects of a ketogenic diet. An increase in the NAD+/NADH ratio is consistent with multiple lines of evidence and hypotheses, and therefore increased NAD+ may be a common mechanism underlying beneficial effects of ketogenic diet therapy." @default.
- W4220731647 created "2022-04-03" @default.
- W4220731647 creator A5018391871 @default.
- W4220731647 creator A5027753317 @default.
- W4220731647 creator A5057138091 @default.
- W4220731647 creator A5086250751 @default.
- W4220731647 date "2022-04-01" @default.
- W4220731647 modified "2023-09-25" @default.
- W4220731647 title "Nicotinamide Adenine Dinucleotide as a Central Mediator of Ketogenic Therapy" @default.
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