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- W4220732877 abstract "Bacteroides thetaiotaomicron is a gut symbiont that inhabits the mucus layer and adheres to and metabolizes food particles, contributing to gut physiology and maturation. Although adhesion and biofilm formation could be key features for B. thetaiotaomicron stress resistance and gut colonization, little is known about the determinants of B. thetaiotaomicron biofilm formation. We previously showed that the B. thetaiotaomicron reference strain VPI-5482 is a poor in vitro biofilm former. Here, we demonstrated that bile, a gut-relevant environmental cue, triggers the formation of biofilm in many B. thetaiotaomicron isolates and common gut Bacteroidales species. We determined that bile-dependent biofilm formation involves the production of the DNase BT3563 or its homologs, degrading extracellular DNA (eDNA) in several B. thetaiotaomicron strains. Our study therefore shows that, although biofilm matrix eDNA provides a biofilm-promoting scaffold in many studied Firmicutes and Proteobacteria, BT3563-mediated eDNA degradation is required to form B. thetaiotaomicron biofilm in the presence of bile." @default.
- W4220732877 created "2022-04-03" @default.
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- W4220732877 date "2022-02-10" @default.
- W4220732877 modified "2023-10-17" @default.
- W4220732877 title "<i>Bacteroides thetaiotaomicron</i> uses a widespread extracellular DNase to promote bile-dependent biofilm formation" @default.
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- W4220732877 doi "https://doi.org/10.1073/pnas.2111228119" @default.
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