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• W4220733844 startingPage "735" @default.
• W4220733844 abstract "Pesticides are a well-known family of chemicals that have contaminated water systems globally. Four common subfamilies of pesticides include organochlorines, organophosphates, pyrethroids, and carbamate insecticides which have been shown to adversely affect the human nervous system. Studies have shown a link between pesticide exposure and decreased viability, proliferation, migration, and differentiation of murine neural stem cells. Besides human exposure directly through water systems, additional factors such as pesticide bioaccumulation, biomagnification and potential synergism due to co-exposure to other environmental contaminants must be considered. A possible avenue to investigate the molecular mechanisms and biomolecules impacted by the various classes of pesticides includes the field of -omics. Discovery of the precise molecular mechanisms behind pesticide-mediated neurodegenerative disorders may facilitate development of targeted therapeutics. Likewise, discovery of pesticide biodegradation pathways may enable novel approaches for water system bioremediation using genetically engineered microorganisms. In this mini-review, we discuss recently established harmful impacts of various categories of pesticides on the nervous system and the application of -omics field for discovery, validation, and mitigation of pesticide neurotoxicity." @default.
• W4220733844 created "2022-04-03" @default.
• W4220733844 creator A5030183751 @default.
• W4220733844 creator A5056642098 @default.
• W4220733844 date "2023-03-01" @default.
• W4220733844 modified "2023-10-17" @default.
• W4220733844 title "Assessment of risks, implications, and opportunities of waterborne neurotoxic pesticides" @default.
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• W4220733844 doi "https://doi.org/10.1016/j.jes.2022.03.033" @default.
• W4220733844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36375955" @default.
• W4220733844 hasPublicationYear "2023" @default.
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