FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220737105> ?p ?o ?g. }

• W4220737105 abstract "One of the many strategies that cancer cells evade death is through up-regulation of the BCL-2 anti-apoptotic proteins. Hence, these proteins have become attractive therapeutic targets. Given that different cell populations rely on different anti-apoptotic proteins for survival, it is crucial to determine which proteins are important for Nasopharyngeal carcinoma (NPC) cell survival. Here we determined the survival requirements for the NPC cells using a combination of the CRISPR/Cas9 technique and selective BH3-mimetics. A human apoptosis RT2 Profiler PCR Array was first employed to profile the anti-apoptotic gene expressions in NPC cell lines HK-1 and C666-1. The HK-1 cells expressed all the anti-apoptotic genes (MCL-1, BFL-1, BCL-2, BCL-XL, and BCL-w). Similarly, the C666-1 cells expressed all the anti-apoptotic genes except BFL-1 (undetectable level). Notably, both cell lines highly expressed MCL-1. Deletion of MCL-1 sensitized the NPC cells to BCL-XL selective inhibitor A-1331852, suggesting that MCL-1 and BCL-XL may be important for NPC cell survival. Co-inhibition of MCL-1 and BCL-2 with MCL-1 selective inhibitor S63845 and BCL-2 selective inhibitor ABT-199 inhibited NPC cell proliferation but the effect on cell viability was more profound with co-inhibition of MCL-1 and BCL-XL with S63845 and A-1331852, implying that MCL-1 and BCL-XL are crucial for NPC cell survival. Furthermore, co-inhibition of MCL-1 and BCL-XL inhibited the growth and invasion of NPC spheroids. Deletion of BFL-1 sensitized NPC cells to A-1331852 suggesting that BFL-1 may play a role in NPC cell survival. Taken together co-inhibition of BCL-XL and MCL-1/BFL-1 could be potential treatment strategies for NPC." @default.
• W4220737105 created "2022-04-03" @default.
• W4220737105 creator A5031882943 @default.
• W4220737105 creator A5045248975 @default.
• W4220737105 creator A5049076363 @default.
• W4220737105 creator A5053289915 @default.
• W4220737105 creator A5090075756 @default.
• W4220737105 date "2022-02-03" @default.
• W4220737105 modified "2023-10-05" @default.
• W4220737105 title "Dual inhibition of anti-apoptotic proteins BCL-XL and MCL-1 enhances cytotoxicity of Nasopharyngeal carcinoma cells" @default.
• W4220737105 cites W1976197588 @default.
• W4220737105 cites W2015141503 @default.
• W4220737105 cites W2035272307 @default.
• W4220737105 cites W2039640090 @default.
• W4220737105 cites W2039879202 @default.
• W4220737105 cites W2050169742 @default.
• W4220737105 cites W2080899323 @default.
• W4220737105 cites W2110525250 @default.
• W4220737105 cites W2118819370 @default.
• W4220737105 cites W2125919881 @default.
• W4220737105 cites W2129219564 @default.
• W4220737105 cites W2131855360 @default.
• W4220737105 cites W2134802480 @default.
• W4220737105 cites W2136910701 @default.
• W4220737105 cites W2137240394 @default.
• W4220737105 cites W2164448776 @default.
• W4220737105 cites W2579747520 @default.
• W4220737105 cites W2735901092 @default.
• W4220737105 cites W2766623255 @default.
• W4220737105 cites W2794583814 @default.
• W4220737105 cites W2800738887 @default.
• W4220737105 cites W2803901601 @default.
• W4220737105 cites W2883155085 @default.
• W4220737105 cites W2942007182 @default.
• W4220737105 cites W3009534642 @default.
• W4220737105 cites W3018288843 @default.
• W4220737105 cites W3020377885 @default.
• W4220737105 cites W3093663086 @default.
• W4220737105 cites W3109505642 @default.
• W4220737105 cites W3116974172 @default.
• W4220737105 cites W3187543078 @default.
• W4220737105 doi "https://doi.org/10.1007/s12672-022-00470-9" @default.
• W4220737105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35201512" @default.
• W4220737105 hasPublicationYear "2022" @default.
• W4220737105 type Work @default.
• W4220737105 citedByCount "2" @default.
• W4220737105 countsByYear W42207371052022 @default.
• W4220737105 crossrefType "journal-article" @default.
• W4220737105 hasAuthorship W4220737105A5031882943 @default.
• W4220737105 hasAuthorship W4220737105A5045248975 @default.
• W4220737105 hasAuthorship W4220737105A5049076363 @default.
• W4220737105 hasAuthorship W4220737105A5053289915 @default.
• W4220737105 hasAuthorship W4220737105A5090075756 @default.
• W4220737105 hasBestOaLocation W42207371051 @default.
• W4220737105 hasConcept C109316439 @default.
• W4220737105 hasConcept C126322002 @default.
• W4220737105 hasConcept C149150037 @default.
• W4220737105 hasConcept C1491633281 @default.
• W4220737105 hasConcept C153911025 @default.
• W4220737105 hasConcept C185592680 @default.
• W4220737105 hasConcept C190283241 @default.
• W4220737105 hasConcept C202751555 @default.
• W4220737105 hasConcept C2776789625 @default.
• W4220737105 hasConcept C2778997737 @default.
• W4220737105 hasConcept C2779707156 @default.
• W4220737105 hasConcept C31573885 @default.
• W4220737105 hasConcept C502942594 @default.
• W4220737105 hasConcept C509974204 @default.
• W4220737105 hasConcept C53227056 @default.
• W4220737105 hasConcept C54355233 @default.
• W4220737105 hasConcept C55493867 @default.
• W4220737105 hasConcept C71924100 @default.
• W4220737105 hasConcept C81885089 @default.
• W4220737105 hasConcept C86803240 @default.
• W4220737105 hasConceptScore W4220737105C109316439 @default.
• W4220737105 hasConceptScore W4220737105C126322002 @default.
• W4220737105 hasConceptScore W4220737105C149150037 @default.
• W4220737105 hasConceptScore W4220737105C1491633281 @default.
• W4220737105 hasConceptScore W4220737105C153911025 @default.
• W4220737105 hasConceptScore W4220737105C185592680 @default.
• W4220737105 hasConceptScore W4220737105C190283241 @default.
• W4220737105 hasConceptScore W4220737105C202751555 @default.
• W4220737105 hasConceptScore W4220737105C2776789625 @default.
• W4220737105 hasConceptScore W4220737105C2778997737 @default.
• W4220737105 hasConceptScore W4220737105C2779707156 @default.
• W4220737105 hasConceptScore W4220737105C31573885 @default.
• W4220737105 hasConceptScore W4220737105C502942594 @default.
• W4220737105 hasConceptScore W4220737105C509974204 @default.
• W4220737105 hasConceptScore W4220737105C53227056 @default.
• W4220737105 hasConceptScore W4220737105C54355233 @default.
• W4220737105 hasConceptScore W4220737105C55493867 @default.
• W4220737105 hasConceptScore W4220737105C71924100 @default.
• W4220737105 hasConceptScore W4220737105C81885089 @default.
• W4220737105 hasConceptScore W4220737105C86803240 @default.
• W4220737105 hasFunder F4320322757 @default.
• W4220737105 hasFunder F4320329006 @default.
• W4220737105 hasIssue "1" @default.
• W4220737105 hasLocation W42207371051 @default.
• W4220737105 hasLocation W42207371052 @default.
• W4220737105 hasLocation W42207371053 @default.

• next