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- W4220739935 endingPage "3485" @default.
- W4220739935 startingPage "3485" @default.
- W4220739935 abstract "C-C motif chemokine ligand 2 (CCL2) is a member of the monocyte chemokine protein family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate inflammation. The CCL2/CCR2 signaling pathway participates in the transduction of neuroinflammatory information between all types of cells in the central nervous system. Animal studies and clinical trials have shown that CCL2/CCR2 mediate the pathological process of ischemic stroke, and a higher CCL2 level in serum is associated with a higher risk of any form of stroke. In the acute phase of cerebral ischemia-reperfusion, the expression of CCL2/CCR2 is increased in the ischemic penumbra, which promotes neuroinflammation and enhances brain injury. In the later phase, it participates in the migration of neuroblasts to the ischemic area and promotes the recovery of neurological function. CCL2/CCR2 gene knockout or activity inhibition can reduce the nerve inflammation and brain injury induced by cerebral ischemia-reperfusion, suggesting that the development of drugs regulating the activity of the CCL2/CCR2 signaling pathway could be used to prevent and treat the cell injury in the acute phase and promote the recovery of neurological function in the chronic phase in ischemic stroke patients." @default.
- W4220739935 created "2022-04-03" @default.
- W4220739935 creator A5022524196 @default.
- W4220739935 creator A5026945057 @default.
- W4220739935 creator A5030513449 @default.
- W4220739935 creator A5041900988 @default.
- W4220739935 creator A5086004920 @default.
- W4220739935 date "2022-03-23" @default.
- W4220739935 modified "2023-10-06" @default.
- W4220739935 title "The Role of CCL2/CCR2 Axis in Cerebral Ischemia-Reperfusion Injury and Treatment: From Animal Experiments to Clinical Trials" @default.
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