FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220740756> ?p ?o ?g. }

• W4220740756 endingPage "2101" @default.
• W4220740756 startingPage "2101" @default.
• W4220740756 abstract "The activation of NLRP3 results in the assembly of inflammasome that regulates caspase-1 activation and the subsequent secretion of bioactive interleukin (IL)-1β. Excessive activation of the NLRP3 inflammasome is mechanistically linked to diverse pathophysiological conditions, including airway inflammation. Here, we discovered that Curcuma phaeocaulis can suppress caspase-1 activation and processing of pro-IL-1β into mature cytokine in macrophages stimulated with NLRP3 inflammasome activators, such as SiO2 or TiO2 nanoparticles. Furthermore, in the bronchoalveolar lavage fluids of animals administered the nanoparticles, the in vitro effects of C. phaeocaulis translated into a decrease in IL-1β levels and cell infiltration. Demethoxycurcumin (DMC) and curcumin were found to be responsible for the inflammasome inhibitory activity of C. phaeocaulis. Interestingly, in contrast to the previously reported higher antioxidant- and NFκB-inhibitory activities of curcumin, DMC exhibited approximately two-fold stronger potency than curcumin against nanoparticle induced activation of NLRP3 inflammasome. In the light of these results, both compounds seem to act independently of their antioxidant- and NFκB-inhibitory properties. Although how C. phaeocaulis inhibits nanoparticle-activated NLRP3 inflammasome remains to be elucidated, our results provide a basis for further research on C. phaeocaulis extract as an anti-inflammatory agent for the treatment of disorders associated with excessive activation of NLRP3 inflammasome." @default.
• W4220740756 created "2022-04-03" @default.
• W4220740756 creator A5009838730 @default.
• W4220740756 creator A5009892479 @default.
• W4220740756 creator A5013844840 @default.
• W4220740756 creator A5025132586 @default.
• W4220740756 creator A5033269943 @default.
• W4220740756 creator A5037823465 @default.
• W4220740756 creator A5046117696 @default.
• W4220740756 creator A5060129111 @default.
• W4220740756 creator A5080612608 @default.
• W4220740756 creator A5082247143 @default.
• W4220740756 creator A5089452267 @default.
• W4220740756 date "2022-03-24" @default.
• W4220740756 modified "2023-10-11" @default.
• W4220740756 title "Curcuma phaeocaulis Inhibits NLRP3 Inflammasome in Macrophages and Ameliorates Nanoparticle-Induced Airway Inflammation in Mice" @default.
• W4220740756 cites W1561041814 @default.
• W4220740756 cites W1966138559 @default.
• W4220740756 cites W1985588649 @default.
• W4220740756 cites W1996087219 @default.
• W4220740756 cites W2009423060 @default.
• W4220740756 cites W2025458374 @default.
• W4220740756 cites W2042433863 @default.
• W4220740756 cites W2078850432 @default.
• W4220740756 cites W2079178816 @default.
• W4220740756 cites W2079882002 @default.
• W4220740756 cites W2079953901 @default.
• W4220740756 cites W2104667669 @default.
• W4220740756 cites W2121166735 @default.
• W4220740756 cites W2132965335 @default.
• W4220740756 cites W2140637559 @default.
• W4220740756 cites W2419269917 @default.
• W4220740756 cites W2521771935 @default.
• W4220740756 cites W2579340176 @default.
• W4220740756 cites W2582259735 @default.
• W4220740756 cites W2593240146 @default.
• W4220740756 cites W2605192232 @default.
• W4220740756 cites W2606093694 @default.
• W4220740756 cites W2792649439 @default.
• W4220740756 cites W2977578303 @default.
• W4220740756 cites W3087276923 @default.
• W4220740756 cites W3130334730 @default.
• W4220740756 cites W3147763922 @default.
• W4220740756 cites W3149086588 @default.
• W4220740756 cites W3195797734 @default.
• W4220740756 cites W3205295338 @default.
• W4220740756 cites W4200296515 @default.
• W4220740756 doi "https://doi.org/10.3390/molecules27072101" @default.
• W4220740756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35408502" @default.
• W4220740756 hasPublicationYear "2022" @default.
• W4220740756 type Work @default.
• W4220740756 citedByCount "5" @default.
• W4220740756 countsByYear W42207407562022 @default.
• W4220740756 countsByYear W42207407562023 @default.
• W4220740756 crossrefType "journal-article" @default.
• W4220740756 hasAuthorship W4220740756A5009838730 @default.
• W4220740756 hasAuthorship W4220740756A5009892479 @default.
• W4220740756 hasAuthorship W4220740756A5013844840 @default.
• W4220740756 hasAuthorship W4220740756A5025132586 @default.
• W4220740756 hasAuthorship W4220740756A5033269943 @default.
• W4220740756 hasAuthorship W4220740756A5037823465 @default.
• W4220740756 hasAuthorship W4220740756A5046117696 @default.
• W4220740756 hasAuthorship W4220740756A5060129111 @default.
• W4220740756 hasAuthorship W4220740756A5080612608 @default.
• W4220740756 hasAuthorship W4220740756A5082247143 @default.
• W4220740756 hasAuthorship W4220740756A5089452267 @default.
• W4220740756 hasBestOaLocation W42207407561 @default.
• W4220740756 hasConcept C139964883 @default.
• W4220740756 hasConcept C170493617 @default.
• W4220740756 hasConcept C185592680 @default.
• W4220740756 hasConcept C187831198 @default.
• W4220740756 hasConcept C203014093 @default.
• W4220740756 hasConcept C2776914184 @default.
• W4220740756 hasConcept C2777209026 @default.
• W4220740756 hasConcept C2778004101 @default.
• W4220740756 hasConcept C2778250585 @default.
• W4220740756 hasConcept C49039625 @default.
• W4220740756 hasConcept C55493867 @default.
• W4220740756 hasConcept C86803240 @default.
• W4220740756 hasConcept C95444343 @default.
• W4220740756 hasConcept C98274493 @default.
• W4220740756 hasConceptScore W4220740756C139964883 @default.
• W4220740756 hasConceptScore W4220740756C170493617 @default.
• W4220740756 hasConceptScore W4220740756C185592680 @default.
• W4220740756 hasConceptScore W4220740756C187831198 @default.
• W4220740756 hasConceptScore W4220740756C203014093 @default.
• W4220740756 hasConceptScore W4220740756C2776914184 @default.
• W4220740756 hasConceptScore W4220740756C2777209026 @default.
• W4220740756 hasConceptScore W4220740756C2778004101 @default.
• W4220740756 hasConceptScore W4220740756C2778250585 @default.
• W4220740756 hasConceptScore W4220740756C49039625 @default.
• W4220740756 hasConceptScore W4220740756C55493867 @default.
• W4220740756 hasConceptScore W4220740756C86803240 @default.
• W4220740756 hasConceptScore W4220740756C95444343 @default.
• W4220740756 hasConceptScore W4220740756C98274493 @default.
• W4220740756 hasIssue "7" @default.
• W4220740756 hasLocation W42207407561 @default.
• W4220740756 hasLocation W42207407562 @default.

• next