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- W4220742007 abstract "Abstract Genetic variants that underlie susceptibility to high-risk cervical human papilloma virus (hrHPV) infections are largely unknown. We conducted discovery case-case and case-control genome-wide association studies, replication, and meta-analysis, generated polygenic risk scores and examined the association of classical HLA alleles and cervical human papillomavirus (HPV) infections in a cohort of over 10,000 women. We identified genome-wide significant variants for prevalent hrHPV around LDB2 and for persistent hrHPV near TPTE2, SMAD2 , and CDH12, which code for proteins that are significantly expressed in the human endocervix. Genetic variants associated with persistent hrHPV are in genes enriched for the antigen processing and presentation gene-set. HLA-DRB1*13:02, HLA-DQB1*05:02 and HLA-DRB1*03:01 were associated with increased risk and HLA-DRB1*15:03 with decreased risk of persistent hrHPV. The findings of this study expand our understanding of genetic risk factors for HPV persistence and highlight the role played by MHC class II molecules in clearing hrHPV after initial infection." @default.
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- W4220742007 date "2022-03-23" @default.
- W4220742007 modified "2023-10-16" @default.
- W4220742007 title "Case-Case and Case-Control Genome-Wide Association Study, Polygenic Risk Score and Classical HLA Alleles Analysis of Cervical Human Papillomavirus (HPV)" @default.
- W4220742007 doi "https://doi.org/10.21203/rs.3.rs-1479565/v1" @default.
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