Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220744489> ?p ?o ?g. }
- W4220744489 endingPage "1796" @default.
- W4220744489 startingPage "1784" @default.
- W4220744489 abstract "Increased cardiac inflammation and oxidative stress are common features in obesity, and toll-like receptor (TLR)4 signaling is a key inflammatory pathway in this deleterious process. This study aimed to investigate whether berries could attenuate the detrimental effects of a high-fat, high-sucrose (HFHS) diet on the myocardium at the molecular level.Eight-week-old male C57BL/6 mice consumed a low-fat, low-sucrose (LFLS) diet alone or supplemented with 10% blackberry (BL), 10% raspberry (RB) or 10% blackberry + raspberry (BL + RB) for four weeks. Animals were then switched to a HFHS diet for 24 weeks with or without berry supplementation or maintained on a LFLS control diet without berry supplementation. Left ventricles of the heart were isolated for protein and mRNA analysis. Berry consumption, particularly BL + RB reduced NADPH-oxidase (NOX)1 and NOX2 and increased catalase (CAT) and superoxide dismutase (SOD)2, expression while BL and RB supplementation alone was less efficacious. Downstream TLR4 signaling was attenuated mostly by both RB and BL + RB supplementation, while NF-κB pathway was attenuated by BL + RB supplementation. Stress-activated protein kinase (SAPK)/Jun amino-terminal kinase (JNK) was also attenuated by BL + RB supplementation, and reduced TNF-α transcription and protein expression was observed only with BL + RB supplementation.The synergistic effects of BL + RB may reduce obesity-induced cardiac inflammation and oxidative stress to a greater extent than BL or RB alone." @default.
- W4220744489 created "2022-04-03" @default.
- W4220744489 creator A5035112932 @default.
- W4220744489 creator A5043004174 @default.
- W4220744489 creator A5055686805 @default.
- W4220744489 creator A5081681409 @default.
- W4220744489 date "2022-07-01" @default.
- W4220744489 modified "2023-10-12" @default.
- W4220744489 title "Raspberry and blackberry act in a synergistic manner to improve cardiac redox proteins and reduce NF-κB and SAPK/JNK in mice fed a high-fat, high-sucrose diet" @default.
- W4220744489 cites W1585390661 @default.
- W4220744489 cites W1752475296 @default.
- W4220744489 cites W1962991582 @default.
- W4220744489 cites W1969268163 @default.
- W4220744489 cites W1977299061 @default.
- W4220744489 cites W1977551186 @default.
- W4220744489 cites W1986241637 @default.
- W4220744489 cites W1988664606 @default.
- W4220744489 cites W1995986855 @default.
- W4220744489 cites W1998986309 @default.
- W4220744489 cites W2000590947 @default.
- W4220744489 cites W2014293957 @default.
- W4220744489 cites W2017016317 @default.
- W4220744489 cites W2017302657 @default.
- W4220744489 cites W2026199993 @default.
- W4220744489 cites W2027179806 @default.
- W4220744489 cites W2033023829 @default.
- W4220744489 cites W2033143975 @default.
- W4220744489 cites W2034580062 @default.
- W4220744489 cites W2050930581 @default.
- W4220744489 cites W2058646994 @default.
- W4220744489 cites W2060785208 @default.
- W4220744489 cites W2066674982 @default.
- W4220744489 cites W2068677664 @default.
- W4220744489 cites W2068905608 @default.
- W4220744489 cites W2070038006 @default.
- W4220744489 cites W2071228656 @default.
- W4220744489 cites W2074988054 @default.
- W4220744489 cites W2082669413 @default.
- W4220744489 cites W2083260532 @default.
- W4220744489 cites W2085128107 @default.
- W4220744489 cites W2086667809 @default.
- W4220744489 cites W2091047906 @default.
- W4220744489 cites W2091525337 @default.
- W4220744489 cites W2091583229 @default.
- W4220744489 cites W2094912457 @default.
- W4220744489 cites W2105259033 @default.
- W4220744489 cites W2105415988 @default.
- W4220744489 cites W2108404291 @default.
- W4220744489 cites W2113974434 @default.
- W4220744489 cites W2114111268 @default.
- W4220744489 cites W2118204731 @default.
- W4220744489 cites W2118492942 @default.
- W4220744489 cites W2120420351 @default.
- W4220744489 cites W2123880723 @default.
- W4220744489 cites W2128338037 @default.
- W4220744489 cites W2145650651 @default.
- W4220744489 cites W2146302436 @default.
- W4220744489 cites W2150081412 @default.
- W4220744489 cites W2152813651 @default.
- W4220744489 cites W2166413996 @default.
- W4220744489 cites W2252524287 @default.
- W4220744489 cites W2268158936 @default.
- W4220744489 cites W2483125756 @default.
- W4220744489 cites W2555348358 @default.
- W4220744489 cites W2564043905 @default.
- W4220744489 cites W2572840791 @default.
- W4220744489 cites W2601569990 @default.
- W4220744489 cites W2672830024 @default.
- W4220744489 cites W2729098679 @default.
- W4220744489 cites W2751518927 @default.
- W4220744489 cites W2894345161 @default.
- W4220744489 cites W2944539222 @default.
- W4220744489 cites W2982640060 @default.
- W4220744489 cites W3002248805 @default.
- W4220744489 cites W3004993505 @default.
- W4220744489 cites W3008060291 @default.
- W4220744489 cites W3011006851 @default.
- W4220744489 cites W3011389733 @default.
- W4220744489 cites W3012975103 @default.
- W4220744489 cites W3033539839 @default.
- W4220744489 cites W3085747716 @default.
- W4220744489 cites W3113090731 @default.
- W4220744489 cites W3126374800 @default.
- W4220744489 cites W3152705473 @default.
- W4220744489 cites W3168991081 @default.
- W4220744489 cites W336659045 @default.
- W4220744489 doi "https://doi.org/10.1016/j.numecd.2022.03.015" @default.
- W4220744489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35487829" @default.
- W4220744489 hasPublicationYear "2022" @default.
- W4220744489 type Work @default.
- W4220744489 citedByCount "4" @default.
- W4220744489 countsByYear W42207444892023 @default.
- W4220744489 crossrefType "journal-article" @default.
- W4220744489 hasAuthorship W4220744489A5035112932 @default.
- W4220744489 hasAuthorship W4220744489A5043004174 @default.
- W4220744489 hasAuthorship W4220744489A5055686805 @default.
- W4220744489 hasAuthorship W4220744489A5081681409 @default.
- W4220744489 hasConcept C126322002 @default.