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- W4220744972 abstract "The formation of a functional organ such as the eye requires specification of the correct cell types and their terminal differentiation into cells with the appropriate morphologies and functions. Here, we show that the zinc-finger transcription factor Blimp-1 acts in secondary and tertiary pigment cells in the Drosophila retina to promote the formation of a bi-convex corneal lens with normal refractive power, and in cone cells to enable complete extension of the photoreceptor rhabdomeres. Blimp-1 expression depends on the hormone ecdysone, and loss of ecdysone signaling causes similar differentiation defects. Timely termination of Blimp-1 expression is also important, as its overexpression in the eye has deleterious effects. Our transcriptomic analysis revealed that Blimp-1 regulates the expression of many structural and secreted proteins in the retina. Blimp-1 may function in part by repressing another transcription factor; Slow border cells is highly upregulated in the absence of Blimp-1, and its overexpression reproduces many of the effects of removing Blimp-1. This work provides insight into the transcriptional networks and cellular interactions that produce the structures necessary for visual function." @default.
- W4220744972 created "2022-04-03" @default.
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- W4220744972 date "2022-03-31" @default.
- W4220744972 modified "2023-10-18" @default.
- W4220744972 title "The Blimp-1 transcription factor acts in non-neuronal cells to regulate terminal differentiation of the <i>Drosophila</i> eye" @default.
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- W4220744972 doi "https://doi.org/10.1242/dev.200217" @default.
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