FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220745751> ?p ?o ?g. }

• W4220745751 endingPage "242" @default.
• W4220745751 startingPage "230" @default.
• W4220745751 abstract "Abstract The accumulation of β-amyloid (Aβ) in the brain plays an important role in the pathogenesis of Alzheimer’s disease (AD). The lack of estrogen is one of the risk factors for AD. Quercetin is a phytoestrogen with a chemical structure similar to that of estrogen. However, the mechanism by which quercetin prevents AD is unclear. PC12 cells were cultured with Aβ 25–35 for 24 h. Then the cells were further treated with 17β-estradiol, genistein, and quercetin for another 24 h, respectively. Next, ICI182780 and U0126 were used to study the mechanisms of estrogen-like neuroprotection. Methyl thiazolyl tetrazolium (MTT) assay was performed to detect cell survival. The protein expression was analyzed by immunofluorescence and western blot. The survival of PC12 cells induced by Aβ 25–35 was increased by quercetin. The levels of estrogen receptor α (ERα) and p-extracellular signal-regulated kinase (ERK)1/2 were improved by quercetin, but not those of ERβ. On the contrary, Bcl-2/Bax was increased and the expression of Caspase-3 was decreased. When the cell was pretreated with ICI182780, the p-ERK1/2 and Bcl-2/Bax ratio was decreased, but Caspase-3 expression was increased. In addition, pretreatment with U0126 would reduce Bcl-2/Bax ratio and increase Caspase-3 protein expression. Conclusively, quercetin plays a neuroprotective role through the ER pathway and the mitogen-activated protein kinase (MAPK) pathway. The MAPK signaling pathways could also be activated by quercetin via the mediation of ERα." @default.
• W4220745751 created "2022-04-03" @default.
• W4220745751 creator A5000432967 @default.
• W4220745751 creator A5004325176 @default.
• W4220745751 creator A5023363049 @default.
• W4220745751 creator A5049720575 @default.
• W4220745751 creator A5067943166 @default.
• W4220745751 creator A5074336661 @default.
• W4220745751 creator A5087855097 @default.
• W4220745751 date "2022-01-01" @default.
• W4220745751 modified "2023-09-27" @default.
• W4220745751 title "Quercetin inhibits cytotoxicity of PC12 cells induced by amyloid-beta 25–35 via stimulating estrogen receptor α, activating ERK1/2, and inhibiting apoptosis" @default.
• W4220745751 cites W2023667812 @default.
• W4220745751 cites W2029225735 @default.
• W4220745751 cites W2034674760 @default.
• W4220745751 cites W2038459954 @default.
• W4220745751 cites W2039851764 @default.
• W4220745751 cites W2043713606 @default.
• W4220745751 cites W2090621194 @default.
• W4220745751 cites W2156167849 @default.
• W4220745751 cites W2499781989 @default.
• W4220745751 cites W2749159529 @default.
• W4220745751 cites W2799873532 @default.
• W4220745751 cites W2890052054 @default.
• W4220745751 cites W2893502892 @default.
• W4220745751 cites W2902110999 @default.
• W4220745751 cites W2927366844 @default.
• W4220745751 cites W2932048204 @default.
• W4220745751 cites W2945679388 @default.
• W4220745751 cites W2950292113 @default.
• W4220745751 cites W2952165249 @default.
• W4220745751 cites W2961042184 @default.
• W4220745751 cites W2964261071 @default.
• W4220745751 cites W2971424763 @default.
• W4220745751 cites W2974422581 @default.
• W4220745751 cites W2978773614 @default.
• W4220745751 cites W2982268567 @default.
• W4220745751 cites W2992999384 @default.
• W4220745751 cites W2997032704 @default.
• W4220745751 cites W3012608664 @default.
• W4220745751 cites W3014251530 @default.
• W4220745751 cites W3025860373 @default.
• W4220745751 cites W4211072901 @default.
• W4220745751 doi "https://doi.org/10.1515/biol-2021-0014" @default.
• W4220745751 hasPublicationYear "2022" @default.
• W4220745751 type Work @default.
• W4220745751 citedByCount "0" @default.
• W4220745751 crossrefType "journal-article" @default.
• W4220745751 hasAuthorship W4220745751A5000432967 @default.
• W4220745751 hasAuthorship W4220745751A5004325176 @default.
• W4220745751 hasAuthorship W4220745751A5023363049 @default.
• W4220745751 hasAuthorship W4220745751A5049720575 @default.
• W4220745751 hasAuthorship W4220745751A5067943166 @default.
• W4220745751 hasAuthorship W4220745751A5074336661 @default.
• W4220745751 hasAuthorship W4220745751A5087855097 @default.
• W4220745751 hasBestOaLocation W42207457511 @default.
• W4220745751 hasConcept C121608353 @default.
• W4220745751 hasConcept C134018914 @default.
• W4220745751 hasConcept C153911025 @default.
• W4220745751 hasConcept C184235292 @default.
• W4220745751 hasConcept C190283241 @default.
• W4220745751 hasConcept C25498285 @default.
• W4220745751 hasConcept C2778004101 @default.
• W4220745751 hasConcept C2778298627 @default.
• W4220745751 hasConcept C2781263971 @default.
• W4220745751 hasConcept C502942594 @default.
• W4220745751 hasConcept C530470458 @default.
• W4220745751 hasConcept C54355233 @default.
• W4220745751 hasConcept C55493867 @default.
• W4220745751 hasConcept C57074206 @default.
• W4220745751 hasConcept C62478195 @default.
• W4220745751 hasConcept C84606932 @default.
• W4220745751 hasConcept C86803240 @default.
• W4220745751 hasConcept C95444343 @default.
• W4220745751 hasConcept C96307122 @default.
• W4220745751 hasConcept C98274493 @default.
• W4220745751 hasConceptScore W4220745751C121608353 @default.
• W4220745751 hasConceptScore W4220745751C134018914 @default.
• W4220745751 hasConceptScore W4220745751C153911025 @default.
• W4220745751 hasConceptScore W4220745751C184235292 @default.
• W4220745751 hasConceptScore W4220745751C190283241 @default.
• W4220745751 hasConceptScore W4220745751C25498285 @default.
• W4220745751 hasConceptScore W4220745751C2778004101 @default.
• W4220745751 hasConceptScore W4220745751C2778298627 @default.
• W4220745751 hasConceptScore W4220745751C2781263971 @default.
• W4220745751 hasConceptScore W4220745751C502942594 @default.
• W4220745751 hasConceptScore W4220745751C530470458 @default.
• W4220745751 hasConceptScore W4220745751C54355233 @default.
• W4220745751 hasConceptScore W4220745751C55493867 @default.
• W4220745751 hasConceptScore W4220745751C57074206 @default.
• W4220745751 hasConceptScore W4220745751C62478195 @default.
• W4220745751 hasConceptScore W4220745751C84606932 @default.
• W4220745751 hasConceptScore W4220745751C86803240 @default.
• W4220745751 hasConceptScore W4220745751C95444343 @default.
• W4220745751 hasConceptScore W4220745751C96307122 @default.
• W4220745751 hasConceptScore W4220745751C98274493 @default.
• W4220745751 hasIssue "1" @default.
• W4220745751 hasLocation W42207457511 @default.

• next