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- W4220746076 endingPage "121" @default.
- W4220746076 startingPage "113" @default.
- W4220746076 abstract "Circadian rhythms are approximately 24-hour cycles of variation in physiological processes, gene expression, and behavior. They result from the interplay of internal biological clocks with daily environmental rhythms, including light/dark and feeding/fasting. Note that 24-hour rhythms of liver metabolic processes have been known for almost 100 years. Modern studies reveal that, like metabolism, hepatic gene expression is highly rhythmic. Genetic or environmental changes can disrupt the circadian rhythms of the liver, leading to metabolic disorders and hepatocellular carcinoma. In this review, we summarize the current understanding of mechanisms regulating rhythmic gene expression in the liver, highlighting the roles of transcription factors that comprise the core clock molecular as well as noncanonical regulators. We emphasize the plasticity of circadian rhythms in the liver as it responds to multiple inputs from the external and internal environments as well as the potential of circadian medicine to impact liver-related diseases." @default.
- W4220746076 created "2022-04-03" @default.
- W4220746076 creator A5061828220 @default.
- W4220746076 creator A5075882004 @default.
- W4220746076 date "2022-03-09" @default.
- W4220746076 modified "2023-09-30" @default.
- W4220746076 title "Circadian Regulation of Gene Expression and Metabolism in the Liver" @default.
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