FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220746163> ?p ?o ?g. }

• W4220746163 abstract "Abstract Background Phosphorus is an essential nutrient in all living organisms and, currently, it is the focus of much attention due to its global scarcity, the environmental impact of phosphorus from excreta, and its low digestibility due to its storage in the form of phytates in plants. In poultry, phosphorus utilization is influenced by composition of the ileum microbiota and host genetics. In our study, we analyzed the impact of host genetics on composition of the ileum microbiota and the relationship of the relative abundance of ileal bacterial genera with phosphorus utilization and related quantitative traits in Japanese quail. An F2 cross of 758 quails was genotyped with 4k genome-wide single nucleotide polymorphisms (SNPs) and composition of the ileum microbiota was characterized using target amplicon sequencing. Heritabilities of the relative abundance of bacterial genera were estimated and quantitative trait locus (QTL) linkage mapping for the host was conducted for the heritable genera. Phenotypic and genetic correlations and recursive relationships between bacterial genera and quantitative traits were estimated using structural equation models. A genomic best linear unbiased prediction (GBLUP) and microbial (M)BLUP hologenomic selection approach was applied to assess the feasibility of breeding for improved phosphorus utilization based on the host genome and the heritable part of composition of the ileum microbiota. Results Among the 59 bacterial genera examined, 24 showed a significant heritability (nominal p ≤ 0.05), ranging from 0.04 to 0.17. For these genera, six genome-wide significant QTL were mapped. Significant recursive effects were found, which support the indirect host genetic effects on the host’s quantitative traits via microbiota composition in the ileum of quail. Cross-validated microbial and genomic prediction accuracies confirmed the strong impact of microbial composition and host genetics on the host’s quantitative traits, as the GBLUP accuracies based on the heritable microbiota-mediated components of the traits were similar to the accuracies of conventional GBLUP based on genome-wide SNPs. Conclusions Our results revealed a significant effect of host genetics on composition of the ileal microbiota and confirmed that host genetics and composition of the ileum microbiota have an impact on the host’s quantitative traits. This offers the possibility to breed for improved phosphorus utilization based on the host genome and the heritable part of composition of the ileum microbiota." @default.
• W4220746163 created "2022-04-03" @default.
• W4220746163 creator A5014989646 @default.
• W4220746163 creator A5025297319 @default.
• W4220746163 creator A5035483766 @default.
• W4220746163 creator A5063826105 @default.
• W4220746163 creator A5072517845 @default.
• W4220746163 creator A5081558621 @default.
• W4220746163 date "2022-03-08" @default.
• W4220746163 modified "2023-10-14" @default.
• W4220746163 title "Composition of the ileum microbiota is a mediator between the host genome and phosphorus utilization and other efficiency traits in Japanese quail (Coturnix japonica)" @default.
• W4220746163 cites W1839169430 @default.
• W4220746163 cites W1911818603 @default.
• W4220746163 cites W1966045122 @default.
• W4220746163 cites W1974741200 @default.
• W4220746163 cites W1979656240 @default.
• W4220746163 cites W1986733619 @default.
• W4220746163 cites W1991600999 @default.
• W4220746163 cites W2016569841 @default.
• W4220746163 cites W2026926325 @default.
• W4220746163 cites W2033151532 @default.
• W4220746163 cites W2035901313 @default.
• W4220746163 cites W2049432953 @default.
• W4220746163 cites W2065158799 @default.
• W4220746163 cites W2067701422 @default.
• W4220746163 cites W2067715889 @default.
• W4220746163 cites W2084266616 @default.
• W4220746163 cites W2089176807 @default.
• W4220746163 cites W2090234656 @default.
• W4220746163 cites W2101010807 @default.
• W4220746163 cites W2101947212 @default.
• W4220746163 cites W2118305361 @default.
• W4220746163 cites W2120017703 @default.
• W4220746163 cites W2126320505 @default.
• W4220746163 cites W2127303481 @default.
• W4220746163 cites W2151350595 @default.
• W4220746163 cites W2156370092 @default.
• W4220746163 cites W2157256905 @default.
• W4220746163 cites W2161377204 @default.
• W4220746163 cites W2162040730 @default.
• W4220746163 cites W2238410827 @default.
• W4220746163 cites W2283329358 @default.
• W4220746163 cites W2401222577 @default.
• W4220746163 cites W2475941389 @default.
• W4220746163 cites W2536360333 @default.
• W4220746163 cites W2554984966 @default.
• W4220746163 cites W2611180177 @default.
• W4220746163 cites W2747463791 @default.
• W4220746163 cites W2762931876 @default.
• W4220746163 cites W2781693763 @default.
• W4220746163 cites W2789888671 @default.
• W4220746163 cites W2799472354 @default.
• W4220746163 cites W2890131564 @default.
• W4220746163 cites W2898031575 @default.
• W4220746163 cites W2904394484 @default.
• W4220746163 cites W2910608302 @default.
• W4220746163 cites W2950395494 @default.
• W4220746163 cites W2956194370 @default.
• W4220746163 cites W2971421917 @default.
• W4220746163 cites W2981075829 @default.
• W4220746163 cites W2982821161 @default.
• W4220746163 cites W2990799724 @default.
• W4220746163 cites W2994168910 @default.
• W4220746163 cites W3023071677 @default.
• W4220746163 cites W3026798585 @default.
• W4220746163 cites W3031805040 @default.
• W4220746163 cites W3036253981 @default.
• W4220746163 cites W3038672098 @default.
• W4220746163 cites W3045432021 @default.
• W4220746163 cites W3095827524 @default.
• W4220746163 cites W3115119353 @default.
• W4220746163 cites W3121190393 @default.
• W4220746163 cites W3125893401 @default.
• W4220746163 cites W3136406193 @default.
• W4220746163 cites W3163038729 @default.
• W4220746163 cites W3192067146 @default.
• W4220746163 cites W3198274722 @default.
• W4220746163 doi "https://doi.org/10.1186/s12711-022-00697-8" @default.
• W4220746163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35260076" @default.
• W4220746163 hasPublicationYear "2022" @default.
• W4220746163 type Work @default.
• W4220746163 citedByCount "5" @default.
• W4220746163 countsByYear W42207461632023 @default.
• W4220746163 crossrefType "journal-article" @default.
• W4220746163 hasAuthorship W4220746163A5014989646 @default.
• W4220746163 hasAuthorship W4220746163A5025297319 @default.
• W4220746163 hasAuthorship W4220746163A5035483766 @default.
• W4220746163 hasAuthorship W4220746163A5063826105 @default.
• W4220746163 hasAuthorship W4220746163A5072517845 @default.
• W4220746163 hasAuthorship W4220746163A5081558621 @default.
• W4220746163 hasBestOaLocation W42207461631 @default.
• W4220746163 hasConcept C104317684 @default.
• W4220746163 hasConcept C135763542 @default.
• W4220746163 hasConcept C153209595 @default.
• W4220746163 hasConcept C161890455 @default.
• W4220746163 hasConcept C18903297 @default.
• W4220746163 hasConcept C2777882087 @default.
• W4220746163 hasConcept C54355233 @default.
• W4220746163 hasConcept C81941488 @default.
• W4220746163 hasConcept C86803240 @default.

• next