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• W4220746687 abstract "Abstract The protozoan pathogen Giardia lamblia is an important worldwide cause of diarrheal disease and malabsorption. Infection is managed with antimicrobials, although drug resistance and treatment failures are a clinical challenge. Prior infection provides significant protection, yet a human vaccine has not been realized. Individual antigens can elicit partial protection in experimental models, but protection is weaker than after prior infection. Here, we developed a multivalent nanovaccine by coating membranes derived from the parasite onto uniform and stable polymeric nanoparticles loaded with a mucosal adjuvant. Intranasal immunization with the nanovaccine induced adaptive immunity and effectively protected mice from G. lamblia infection." @default.
• W4220746687 created "2022-04-03" @default.
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• W4220746687 date "2022-03-09" @default.
• W4220746687 modified "2023-10-06" @default.
• W4220746687 title "Codelivery of Antigens and Adjuvant in Polymeric Nanoparticles Coated With Native Parasite Membranes Induces Protective Mucosal Immunity Against <i>Giardia lamblia</i>" @default.
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• W4220746687 doi "https://doi.org/10.1093/infdis/jiac074" @default.
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