Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220749059> ?p ?o ?g. }
- W4220749059 abstract "Microbial coculture engineering has emerged as a promising strategy for biomanufacturing. Stability and self-regulation pose a significant challenge for the generation of intrinsically robust cocultures for large-scale applications. Here, we introduce the use of multi-metabolite cross-feeding (MMCF) to establish a close correlation between the strains and the design rules for selecting the appropriate metabolic branches. This leads to an intrinicially stable two-strain coculture where the population composition and the product titer are insensitive to the initial inoculation ratios. With an intermediate-responsive biosensor, the population of the microbial coculture is autonomously balanced to minimize intermediate accumulation. This static-dynamic strategy is extendable to three-strain cocultures, as demonstrated with de novo biosynthesis of silybin/isosilybin. This strategy is generally applicable, paving the way to the industrial application of microbial cocultures." @default.
- W4220749059 created "2022-04-03" @default.
- W4220749059 creator A5013378849 @default.
- W4220749059 creator A5014978931 @default.
- W4220749059 creator A5050738451 @default.
- W4220749059 creator A5051098970 @default.
- W4220749059 creator A5055089298 @default.
- W4220749059 creator A5064136336 @default.
- W4220749059 creator A5075355713 @default.
- W4220749059 creator A5091401063 @default.
- W4220749059 date "2022-03-23" @default.
- W4220749059 modified "2023-10-14" @default.
- W4220749059 title "Design of stable and self-regulated microbial consortia for chemical synthesis" @default.
- W4220749059 cites W1861537611 @default.
- W4220749059 cites W1958250075 @default.
- W4220749059 cites W1995976759 @default.
- W4220749059 cites W1998240064 @default.
- W4220749059 cites W2018191616 @default.
- W4220749059 cites W2021112085 @default.
- W4220749059 cites W2029512487 @default.
- W4220749059 cites W2029945156 @default.
- W4220749059 cites W2076393137 @default.
- W4220749059 cites W2078779451 @default.
- W4220749059 cites W2084140927 @default.
- W4220749059 cites W2095355446 @default.
- W4220749059 cites W2101051206 @default.
- W4220749059 cites W2116137883 @default.
- W4220749059 cites W2116780346 @default.
- W4220749059 cites W2119368614 @default.
- W4220749059 cites W2122093325 @default.
- W4220749059 cites W2145352273 @default.
- W4220749059 cites W2167574642 @default.
- W4220749059 cites W2169010693 @default.
- W4220749059 cites W2268117688 @default.
- W4220749059 cites W2324377386 @default.
- W4220749059 cites W2402262832 @default.
- W4220749059 cites W2544859878 @default.
- W4220749059 cites W2548316814 @default.
- W4220749059 cites W2625497715 @default.
- W4220749059 cites W2761891951 @default.
- W4220749059 cites W2775630394 @default.
- W4220749059 cites W2778600375 @default.
- W4220749059 cites W2794978358 @default.
- W4220749059 cites W2800771128 @default.
- W4220749059 cites W2883828272 @default.
- W4220749059 cites W2897355487 @default.
- W4220749059 cites W2899128614 @default.
- W4220749059 cites W2903216094 @default.
- W4220749059 cites W2909280598 @default.
- W4220749059 cites W2913130535 @default.
- W4220749059 cites W2913553075 @default.
- W4220749059 cites W2920434183 @default.
- W4220749059 cites W2930102738 @default.
- W4220749059 cites W2948290062 @default.
- W4220749059 cites W2979985476 @default.
- W4220749059 cites W2980560152 @default.
- W4220749059 cites W2984439607 @default.
- W4220749059 cites W2989619126 @default.
- W4220749059 cites W3000153187 @default.
- W4220749059 cites W3004010900 @default.
- W4220749059 cites W3015624202 @default.
- W4220749059 cites W3018051732 @default.
- W4220749059 cites W3023610329 @default.
- W4220749059 cites W3032700810 @default.
- W4220749059 cites W3044445219 @default.
- W4220749059 cites W3080506686 @default.
- W4220749059 cites W3083459141 @default.
- W4220749059 cites W3096266289 @default.
- W4220749059 cites W3177442166 @default.
- W4220749059 cites W3182714282 @default.
- W4220749059 doi "https://doi.org/10.1038/s41467-022-29215-6" @default.
- W4220749059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35322005" @default.
- W4220749059 hasPublicationYear "2022" @default.
- W4220749059 type Work @default.
- W4220749059 citedByCount "30" @default.
- W4220749059 countsByYear W42207490592022 @default.
- W4220749059 countsByYear W42207490592023 @default.
- W4220749059 crossrefType "journal-article" @default.
- W4220749059 hasAuthorship W4220749059A5013378849 @default.
- W4220749059 hasAuthorship W4220749059A5014978931 @default.
- W4220749059 hasAuthorship W4220749059A5050738451 @default.
- W4220749059 hasAuthorship W4220749059A5051098970 @default.
- W4220749059 hasAuthorship W4220749059A5055089298 @default.
- W4220749059 hasAuthorship W4220749059A5064136336 @default.
- W4220749059 hasAuthorship W4220749059A5075355713 @default.
- W4220749059 hasAuthorship W4220749059A5091401063 @default.
- W4220749059 hasBestOaLocation W42207490591 @default.
- W4220749059 hasConcept C105702510 @default.
- W4220749059 hasConcept C127413603 @default.
- W4220749059 hasConcept C144024400 @default.
- W4220749059 hasConcept C149923435 @default.
- W4220749059 hasConcept C150903083 @default.
- W4220749059 hasConcept C181199279 @default.
- W4220749059 hasConcept C183696295 @default.
- W4220749059 hasConcept C185592680 @default.
- W4220749059 hasConcept C191908910 @default.
- W4220749059 hasConcept C2775893736 @default.
- W4220749059 hasConcept C2777477808 @default.
- W4220749059 hasConcept C2778022156 @default.
- W4220749059 hasConcept C2908647359 @default.