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- W4220755384 abstract "The ability of phytochromes to act as photoswitches in plants and microorganisms depends on interactions between a bilin-like chromophore and a host protein. The interconversion occurs between the spectrally distinct red (Pr) and far-red (Pfr) conformers. This conformational change is triggered by the photoisomerization of the chromophore D-ring pyrrole. In this study, as a representative example of a phytochrome-bilin system, we consider biliverdin IXα (BV) bound to bacteriophytochrome (BphP) from Deinococcus radiodurans. In the absence of light, we use an enhanced sampling molecular dynamics (MD) method to overcome the photoisomerization energy barrier. We find that the calculated free energy (FE) barriers between essential metastable states agree with spectroscopic results. We show that the enhanced dynamics of the BV chromophore in BphP contributes to triggering nanometer-scale conformational movements that propagate by two experimentally determined signal transduction pathways. Most importantly, we describe how the metastable states enable a thermal transition known as the dark reversion between Pfr and Pr, through a previously unknown intermediate state of Pfr. We present the heterogeneity of temperature-dependent Pfr states at the atomistic level. This work paves a way toward understanding the complete mechanism of the photoisomerization of a bilin-like chromophore in phytochromes." @default.
- W4220755384 created "2022-04-03" @default.
- W4220755384 creator A5003660105 @default.
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- W4220755384 creator A5069970299 @default.
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- W4220755384 date "2022-03-31" @default.
- W4220755384 modified "2023-10-14" @default.
- W4220755384 title "Enhancing the Inhomogeneous Photodynamics of Canonical Bacteriophytochrome" @default.
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- W4220755384 doi "https://doi.org/10.1021/acs.jpcb.2c00131" @default.
- W4220755384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35357137" @default.
- W4220755384 hasPublicationYear "2022" @default.
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