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- W4220756527 abstract "Metabolism of insecticides is an energy-consuming process. As an important component of the intracellular energy buffering system, arginine kinase (AK) plays an important role in insect cellular energy homeostasis and environmental stress response, but the involvement of AKs in the response to chemical stressors (insecticides) remains largely unknown. In this study, using Tribolium castaneum as a model organism, we found that deltamethrin treatment significantly upregulated the expression of TcAK1 and TcAK2 and decreased the whole body ATP content. The knockdown of TcAK1 or TcAK2 significantly enhances the deltamethrin-induced ATP depletion and increase the susceptibility of T. castaneum to deltamethrin. In addition, pretreatment with two AK inhibitors, rutin and quercetin, significantly decreased the lifespan of beetles treated with deltamethrin. These results suggest that AKs might be involved in detoxification of insecticides by regulating cellular energy balance." @default.
- W4220756527 created "2022-04-03" @default.
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- W4220756527 date "2022-05-01" @default.
- W4220756527 modified "2023-10-18" @default.
- W4220756527 title "Knockdown or inhibition of arginine kinases enhances susceptibility of Tribolium castaneum to deltamethrin" @default.
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- W4220756527 doi "https://doi.org/10.1016/j.pestbp.2022.105080" @default.
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